量效曲线实验微机化及其作图的优化  

Computerization of Dose Response Curve Experiment and Its Optimizationin Graph Making

作　　者：庄学煊[1] 石刚刚[1] 晏义平[1] 尹俊[1] 张映娜[1] 

机构地区：[1]汕头大学医学院药理教研室,汕头515031

出　　处：《汕头大学医学院学报》1999年第1期78-80,共3页Journal of Shantou University Medical College

摘　　要：采用MS302生物信号记录分析系统，使量反应量效曲线实验微机化，可明显改善原始记录图像的质量；其光标测量技术提高了实测效应数据的准确性和可靠性。将实测效应（E）经线性回归处理，求得期望效应（E），再按栏绘制量效曲线图。其S型比较典型，图标KD值（解离常数）与理论计算值相符，比按实测效应作图效果明显优化。The qUality of original recoil pob was obviously improved by using MS302 bio~ reCOil analpingsystem to make dOSe -- responSe curve (DRC) experiment computerics. The highlight meaSUrement inc~ theaccrsy and credibility of actual measured daal. The expeCted effect (E) was obtained by linear ~ion of aCtualmeasured effeCt (E). Then DRC of dose nahon was made, the S -- shape curve was ~ typical and graph -- malledKD value was in accoldance with that of lheorehcal calculahon. The curve effect made ho ~ effect (E) was betterthan that from actual measured effect.

关 键 词：量反应 量效曲线 期望效应 微机化 受体药理学 

分 类 号：R966[医药卫生—药理学] R965.2[医药卫生—药学]