不同黄连炮制品“止消渴”药效学比较研究  

Comparison in pharmacodynamic effects of different types of processed Rhizoma Coptis on mouse diabetes

作　　者：李佳川[1] 孟宪丽[1] 崔蓉[1] 赖先荣[1] 范昕建[1] 曾勇[1] 

机构地区：[1]成都中医药大学,四川成都611137

出　　处：《中成药》2010年第11期1922-1925,共4页Chinese Traditional Patent Medicine

基　　金："十一五"国家科技支撑计划地方专项(2007BAI40B03;2007BAI40B05);成都中医药大学科技发展基金重点项目(ZRZD200801);成都中医药大学学生科研实践创新课题(013-011-37)

摘　　要：目的:探索不同黄连炮制品(萸炙、酒炙、酒蒸、姜炙、醋炙黄连及黄连生品)在"止消渴"方面的药效差异,为黄连治疗2型糖尿病的临床有效用药提供科学依据。方法:分别观察不同黄连炮制品对正常小鼠血糖以及对高浓度葡萄糖诱导的小鼠急性高血糖模型、四氧嘧啶诱导的糖尿病小鼠模型和链脲佐菌素联合高脂饮食诱导的2型糖尿病小鼠模型相关生化指标的影响,并运用聚类分析分析其结果。结果:不同黄连炮制品能明显降低小鼠四氧嘧啶糖尿病模型和小鼠STZ高脂复合2型糖尿病模型血清GSP和FBG的含量;其中黄连炮制品萸炙、酒炙和酒蒸黄连还能明显降低高浓葡萄糖引起的小鼠血糖急性升高,降低小鼠STZ高脂复合2型糖尿病模型血清TC和TG的含量,改善糖脂代谢紊乱,且各炮制品对正常血糖水平均无明显影响。结论:中药黄连"止消渴"疗效确切,尤以黄连萸炙、酒炙和酒蒸3种炮制品在改善胰岛素抵抗,降低血糖,改善糖脂代谢紊乱等方面作用优于黄连生品,且对正常血糖水平无明显影响。AIM：To explore various pharmacodynamic effects of different types of Rhizoma Coptis processed products with Fructus Evodiae juice,with wine,with steaming wine,with Ginger juice,with vinegar and crude Rhizoma Coptis＂antidiabetes＂,to treat the type 2 diabetes.METHODS：Mouse models of diabetes were induced by strong glucose solution,alloxan and streptozotocin in combination with high fat-food,the impact of processed products of Rhizoma Coptis on the blood glucose level of experiment mouse were observed,normal mice as the con-trol group,and their related biochemical indexes were measured,and clustering analysis was used to analyze the re-sults.RESULTS：The result showed all processed Rhizoma Coptis could clearly reduce GSP and FBG of mice in-duced by alloxan and streptozotocin plus high fat-food;the coptdis by steaming with wine and evodia juice and wine could clearly reduce acutely increase in blood glucose level of mice induced by strong glucose solution,reduce the serum triglyceride and cholesterol of mice induced by streptozotocin plus high fat-food,improve the metabolic disor-der of glucolipid,all of which had no markedly influence on the glucose level of normal.CONCLUSION：The re-sult indicates Rhizoma Coptis＂antidiabetes＂has an exact therapeutic effect,especially Rhizoma Coptis by steaming with wine and with evodia juice,and with wine;these three processed products in comparison with crude Rhizoma Coptis have better effect on insulin resistance due to reduction in blood glucose and metabolization.

关 键 词：黄连 炮制品 止消渴 药效评价 

分 类 号：R283[医药卫生—中药学]