甲氨蝶呤药物损害事件中可疑药物的论证  

Demonstration of Suspicious Drugs in the Methotrexate Adverse Drug Event

作　　者：王劲[1] 陈龙英[1] 刘滔滔[1] 唐双意[1] 陆华[1] 杨天燕[1] 

机构地区：[1]广西医科大学第一附属医院药剂科,南宁市530027

出　　处：《中国药房》2010年第44期4194-4196,共3页China Pharmacy

摘　　要：目的:介绍2007年我院甲氨蝶呤药物损害事件中可疑药品的排查方法,为今后发生类似事件提供可借鉴的经验与方法。方法:通过调查病区医嘱的执行记录,查询一级药库、二级药库领用数据确定病区领用4种鞘内注射药品的时间。采用计算药品不良反应出现的迟发期给可疑药品排序、设定时间分隔点调查患者病情2种方法确定可疑药品。结果:上海医药(集团)有限公司华联制药厂生产的注射用甲氨蝶呤(5mg,批号:070403A)是此次药物损害事件中唯一可疑药品。结论:甲氨蝶呤药物损害事件中可疑药品的排查方法是可行的,可在类似药品不良事件中应用。OBJECTIVE：To introduce the investigation method of methotrexate adverse drug event（ADE）in our hospital in 2007,and to provide experience and method for similar incidents in the future.METHODS：To investigate the performance of medical records in ward,and retrieve the application records of the first and the second pharmacy warehouse,make clear the application time involving in the 4 sorts of intrathecal injection drugs about the ward.To determine the suspicious drug with 2 methods：calculate the late-onset time of drug adverse reaction to sort the suspicious drugs;set divide point of time to investigate patients＇ disease state.RESULTS：Methotrexate for injection（5 mg,batch number 070403A） produced by Shanghai Pharmaceutical（Group）Co.,Ltd.Shanghai Hualian Pharmaceutical Factory was the only suspicious drug in the ADE.CONCLUSION：The investigation method of suspicious drug in the ADE is feasible and should be promoted for similar ADE in clinical practice.

关 键 词：甲氨蝶呤 药物损害 药品不良事件 

分 类 号：R969.3[医药卫生—药理学] R952[医药卫生—药学]