抗病毒治疗过程中慢性乙型肝炎患者外周血浆IL-18、IP-10水平变化及临床意义  

Level changes and clinical significance of plasma IL-18,IP-10 in patients with chronic hepatitis B during antiviral treatment

作　　者：赵学辉[1,2] 杨介钻[2] 魏丽[2] 胡云良[1] 李兰娟[2] 

机构地区：[1]温州医学院附属二院检验科,浙江温州325027 [2]浙江大学医学院附属一院传内科,杭州310003

出　　处：《中国卫生检验杂志》2010年第11期2852-2853,共2页Chinese Journal of Health Laboratory Technology

基　　金：国家重点基础研究发展规划(2007CB513003);浙江省医药卫生基金(2007A071)

摘　　要：目的:检测慢性乙型肝炎(CHB)患者外周血浆中细胞因子IL-18、IP-10水平在抗病毒治疗过程中不同时期的水平,并探讨其临床意义。方法:用双抗体夹心ELISA法定量检测33例CHB患者抗病毒治疗不同时期的血浆IL-18、IP-10水平,并同时检测其肝功能。结果:抗病毒治疗后,血浆IL-18、IP-10及血清ALT水平有明显的下降,治疗后第12周、第24周与治疗前比较差别均有统计学意义(P<0.05),且IL-18、IP-10与ALT呈正相关(r分别为0.269、0.656,P值分别为P<0.05、P<0.01)。结论:IL-18、IP-10在慢乙肝患者肝脏免疫损伤中发挥重要作用,监测抗病毒治疗过程中血浆IL-18、IP-10水平变化有助于了解机体免疫动态,评价抗病毒药物疗效。Objective：To observe the levels of interleukin-18（IL-18）,interferon-inducible protein-10（IP-10） in plasma of patients with chronic hepatitis B（CHB） in the process of antiviral treatment,and further analysis its clinical significance.Methods：Plasma levels of IL-18,IP-10 in 33 patients with CHB at different antiviral stages were determined by double antibody sandwich ELISA,and their biochemical indicator of liver function was determined at the same time.Results：Levels of both IL-18 and IP-10 in the 12th and 24th week after antiviral treatment are lower than that of the prior treatment（P0.05）.After antiviral treatment,the levels of IL-18 and IP-10 are positively correlated with alanine transaminase′s（ALT）（r=0.269,0.656,P0.05,P0.01）.Conclusion：Both IL-18 and IP-10 in the plasma of patients with CHB may play important roles in immune damage of liver cells.Monitoring plasma levels of IL-18 and IP-10 in the process of antiviral treatment can be used to reveal the immune statue and evaluate the efficacy of antiviral drug.

关 键 词：慢性乙型肝炎 抗病毒治疗 细胞因子 临床意义 

分 类 号：R512.62[医药卫生—内科学]