钆特醇及钆喷替酸葡甲胺在1.5、3.0 TMR下鼠脑胶质瘤模型增强扫描中的应用比较研究  

Comparative evaluation of gadoteridol versus gadopentetate dimeglumine for contrast-enhanced MRI in a rat brain glioma model at 1.5 and 3.0 T

作　　者：艾飞[1] Val M Runge John N Morelli Lan.Vu Jeremy Cannel Alan T Loynachan 漆剑频[1] 李小明[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院放射科,武汉430030 [2]Department of Radiology, Scott & White Memorial Hospital, Texas A&M University, Temple, Texas, USA 76508 [3]Livestock Disease Diagnostic Center, University of Kentucky, College of Agriculture, Lexington, KY 40511-4125, USA 40506

出　　处：《中华放射学杂志》2010年第11期1197-1203,共7页Chinese Journal of Radiology

摘　　要：目的 对比钆特醇及Gd-DTPA在1.5及3.0 T MR下的增强效果,比较两者在增强扫描中的应用价值.方法 42只CDF Fisher 344雄性大鼠,采用经皮导管脑内接种胶质瘤细胞,培育1周,制作鼠脑胶质瘤模型.将大鼠采用数字表法随机分为4组,分别为12、10、10、10只,进行1.5及3.0 T MR下注射钆特醇及Gd-DTPA增强效果对比、注射钆特醇在1.5及3.0 T两种场强下增强效果对比、1.5 T MR下使用标准剂量钆特醇与3.0 T下使用半剂量增强效果对比.两次扫描间隔24 h.选取注射对比剂前及注射后第1、3、5、7、9分钟时间点的T1加权图像,利用影像工作站分析计算各图像的信噪比（signal to noise ratio,SNR）,对比噪声比（contrast to noise ratio,CNR）及对比增强比（contrast enhancement,CE）,所得数据选用Student配对双尾t检验行统计学分析.结果 1.5 T MR下,注射Gd-DTPA后各时间点图像SNR、CNR和CE平均值分别为54.4±3.2、17.0±3.3、20.8±3.4;注射钆特醇后各值分别为53.2±3.2、17.2±3.1、20.8±3.2,两者差异无统计学意义（t值分别为2.247、0.403、0.076,P值均＞0.05）.3.0 T MR下,注射Gd-DTPA后各时间点图像SNR、CNR和CE平均值分别为94.8±7.1、38.0±6.0、45.0±6.3;注射钆特醇后各值分别为95.5±2.9、37.2±2.7、45.6±2.8,两者差异亦无统计学意义（t值分别为0.303、0.573、0.357,P值均＞0.05）.注射钆特醇在1.5 T MR下增强扫描后各时间点图像SNR、CNR和CE平均值分别为51.9±3.0、15.6±3.0、18.6±3.0;在3.0 T MR下图像各值分别为86.1±4.9、27.4±5.0、37.3±5.3,均高于1.5 T MRI图像,差异有统计学意义（t值分别为36.227、11.977、17.106,P值均＜0.05）.1.5 T MR下注射标准剂量钆特醇增强扫描后,各时间点图像SNR、CNR和CE平均值分别为53.8±1.6、17.7±1.7、20.3±1.6;3.0 T MR下注射半剂量钆特醇增强图像各值分别为72.2±2.4、15.4±2.4、21.1±2.4,两者SNR、CNR均值差异有统计学意义（t值分别为31.503、5.137,P值均Objective To compare gadoteridol and gadopentetate dimeglumine （Gd-DTPA） with respect to lesion enhancement in a rat brain glioma model at 1.5 and 3.0 T. Methods Glioma cells were injected into the brains of 42 male CDF （ Fisher 344） rats through implanted cannula to create Glioma animal model. One week after implantation, all rats were randomly divided in to four groups which included 12,10,10,10 rats. The comparisons included the contrast effect of gadoteridol versus gadopentetate dimeglumine at both 1.5 and 3.0 T. In addition, gadoteridol alone was evaluated by comparing the standard dose at both two field strengths and half dose at 3.0 T to a standard full dose at 1.5 T. Two MRI scans for different contrast agent injections were performed in each animal model with an interval of 24 hours. T1 -weighted images were analyzed pre-contrast and at five time points （ 1, 3, 5, 7 and 9 min） post-contrast with respect to lesion signal-to-noise ratio （SNR）, contrast-to-noise ratio （CNR）, and contrast enhancement （CE）. Student t test was used for statistics. Results The mean SNR, CNR, and CE were respectively 54. 4 ± 3. 2, 17.0 ± 3.3 and 20. 8 ± 3.4 with gadopentetate dimeglumine versus 53.2 ± 3.2, 17.2 ± 3. 1 and 20. 8 ± 3.2 with gadoteridol at 1.5 T at every postcontrast time point （ t = 2. 247, 0. 403, 0. 076, P ＞ 0. 05 ）. The mean SNR, CNR, and CE were respectively 94.8 ± 7.1, 38.0 ± 6.0 and 45.0 ± 6.3 with gadopentetate dimeglumine versus 95.5 ± 2. 9, 37.2 ± 2. 7 and 45.6 ± 2. 8 with gadoteridol at 3.0 T （ t = 0. 303, 0. 573,0. 357 ,P ＞ 0. 05 ）. No statistically significant differences were found in these parameters between the two agents at any time point at either field strength. Standard dose gadoteridol demonstrated significant improvements in SNR （51.9 ±3.0 at 1.5 T vs 86. 1 ±4.9 at 3.0 T）, CNR （15.6 ±3.0 at 1.5 T vs 27.4±5.0 at 3.0 T） and CE （18.6 ±3.0 at 1.5 Tvs 37.3 ±5.3 at 3.0 T） at 3.0 T as compared to 1.5 T at every time post-contrast （t

关 键 词：造影剂 对比研究 神经胶质瘤 模型 动物 

分 类 号：R686[医药卫生—骨科学]