抗病毒和肝动脉插管栓塞化疗联合应用对乙肝相关性肝癌术后复发的影响  

Effects of anti-viral therapy in combination with transcatheter arteria chemoembolization on recurrence of HBVrelated hepatocellular carcinoma after operation

作　　者：倪俊[1] 严强[1] 袁文斌[1] 张鸣杰[1] 张国雷[1] 

机构地区：[1]湖州市中心医院外科,浙江313000

出　　处：《中华肝胆外科杂志》2010年第10期751-753,共3页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的 分析抗病毒与肝动脉插管栓塞化疗（transcatheter arteria chemoembolization,TACE）联合应用对乙肝相关性肝癌切除术后复发的预防疗效.方法 按照入选标准,2003年1月至2009年6月共43例入选,分为联合预防组和对照组分别对术后的累积无瘤生存率、累积生存率以及1、2、3年复发率和累积复发率进行回顾性对照研究.结果 联合预防组术后累积无瘤生存率、累积生存率均明显优于对照组,P值分别为0.019和0.008.联合预防组与对照组对比,1、2、3年复发率分别为24%比38.9%,28%比33.3%,28%比22.2%;1、2、3年累积复发率分别为24%比38.9%,52%比72.2%,80%比94.4%.结论 抗病毒和TACE联合预防对于肝癌切除术后复发的预防有较为明显的疗效.Objective To investigate the preventive effects of anti-viral therapy in combination with transcatheter arteria chemoembolization （TACE） on recurrence of HBV-related hepatocellular carcinoma （HCC） after operation. Methods According to selection standards, 49 patients treated in this hospital from January 2003 to June 2009 were enrolled in this study and divided into a control group and combined group.The cumulative tumor-free survival rate, cumulative survival rate, the 1-, 2- and 3-year recurrence rates and cumulative recurrence rates were determined in all the patients and compared between the 2 groups. Results The cumulative tumor-free survival rate and cumulative survival rate were significantly higher in the combined group than in the control group （P=0. 019, 0. 008）. The 1-, 2-, and 3-recurrence rates were 24% vs. 38.9%, 28% vs. 33.3%, and 28% vs. 22.2% in the combined group and control group, respectively. The 1-, 2-, and 3-year cumulative recurrence rates were 24% vs. 38. 9%, 52% vs. 72. 2%, and 80% vs.94. 4% in the combined group and control group, respectively. Conclusion Anti-viral therapy in combination with TACE can exert significant preventive effects on recurrence of HBV-related HCC after operation.

关 键 词：肝细胞癌 抗病毒治疗 肝动脉插管化疗 复发 

分 类 号：R686[医药卫生—骨科学]