吡格列酮下调糖尿病大鼠肾脏组织缺氧诱导因子1α及血管内皮生长因子的表达  

Effects of pioglitazone on the expressions of HIF-1α and VEGF in renal tissues of diabetic rats

作　　者：徐向进[1] 陈频[1] 郑全林[1] 王艳桥[1] 陈文钰[1] 

机构地区：[1]南京军区福州总医院内分泌科,福州350025

出　　处：《中华内分泌代谢杂志》2010年第10期885-888,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：福建省自然科学基金（2008J0104）

摘　　要：观察吡格列酮对糖尿病大鼠肾小球缺氧诱导因子1α（HIF-1α）及血管内皮生长因子（VEGF）表达的影响.高糖高脂饲料喂养及腹腔注射链脲佐菌素建立糖尿病模型并予以吡格列酮治疗,经治疗的大鼠肾脏肥大指数、24 h尿微量白蛋白、尿素氮、肌酐、空腹血糖、空腹胰岛素、胰岛素抵抗指数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇均明显降低,高密度脂蛋白胆固醇明显升高,肾小球HIF-1α和VEGF表达降低（均P＜0.01）.提示吡格列酮具有改善糖尿病大鼠糖脂代谢和肾功能的作用,机制可能与调控HIF-1/VEGF缺氧反应通路相关.The effects of pioglitazone on the expressions of hypoxia-inducible factor-1 α （HIF-1 α） and vascular endothelial growth factor （VEGF） in renal tissues of diabetic rats were observed. Diabetic rat model was established by feeding high-carbonhydrate-fat diet and injecting streptozotocin. After the treatment with pioglitazone, the kidney index, 24 h urinary albumin, blood urea nitrogen, serum creatinine, fasting blood glucose, fasting insulin, homeostasis model assessment for insulin resistance （HOMA-IR）, total cholesterol,triglycerides, and low-density lipoprotein-cholesterol of diabetic rats were significantly lower than those of untreated ones, high-density lipoprotein-cholesterol was increased, the expressions of HIF-1α and VEGF in renal tissue were decreased （ all P〈0. 01 ）. It suggested that pioglitazone may improve renal function and the balance of glucose-lipid metabolism in diabetic rats via down-regulating HIF-1/VEGF pathway.

关 键 词：糖尿病 实验性 缺氧诱导因子1Α 血管内皮生长因子 吡格列酮 

分 类 号：R686[医药卫生—骨科学]