肾心宁方结合西医常规疗法治疗慢性肾功能不全心脏病变的临床研究  

Clinical study on combined "Shenxinning Decoction" and routine therapy for heart disease following chronic renal insufficiency

作　　者：杨雪军[1] 刘伟芳[2] 何立群[1] 

机构地区：[1]上海中医药大学附属曙光医院肾内科,上海200021 [2]上海中医药大学,2010级硕士生上海201203

出　　处：《上海中医药杂志》2010年第11期39-42,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(30873262);上海中医药大学杏林学者计划项目(2010);上海市教育委员会E-研究院建设计划项目(E03008);上海市教委高校创新团队项目(2009)

摘　　要：目的观察肾心宁方结合西医常规疗法治疗慢性肾功能不全心脏病变的临床疗效。方法采用随机平行对照法,将70例患者随机分为治疗组和对照组(各35例);对照组采用西医常规疗法,治疗组在此基础上同时予肾心宁方;两组疗程均为4个月,观察临床疗效、中医证候疗效及血常规、肾功能、24h尿蛋白、EKG、UCG、血清K+变化情况。结果治疗组临床、中医证候总有效率分别为63.33%和90.00%,对照组分别为55.88%和17.65%;组间比较,中医证候疗效差异有统计学意义(P<0.05)。治疗组在改善腰酸乏力、畏寒、胸闷胸痛气短气急、便秘、舌苔等方面优于治疗组(P<0.05)。治疗组治疗后Scr明显降低(P<0.05),对照组明显升高(P<0.05);组间治疗后比较,Scr差异有统计学意义(P<0.05)。治疗组治疗前后RBC、Hb、SBP差异有统计学意义(P<0.05),对照组无明显变化(P>0.05);组间治疗后比较,各指标差异均无统计学意义(P>0.05)。治疗组治疗前后EF值差异有统计学意义(P<0.05);组间超声心动图治疗后比较,各观察项目差异均无统计学意义(P>0.05)。结论肾心宁方结合西医常规疗法对改善慢性肾功能不全心脏病变疗效确切。Objective To observe the clinical efficacy of combined ＂Shenxinning Decoction＂ and routine therapy for heart disease following chronic renal insufficiency. Methods Seventy subjects were randomized into two groups： control group in which 35 cases were treated by routine therapy, and treatment group in which 35 cases by combined ＂Shenxinning Decoction＂ and routine therapy, with a course of four months; the clinical efficacy, syndrome effect, blood routine, renal function, 24-hour urinary protein, EKG, UCG and serum K＋ were observed. Results： The total effective rates of clinical efficacy and syndrome effect were 63.33% and 90.00% in the treatment group, 55.88% and 17.65% in the control group, with a difference in the syndrome effect between the two groups（P0.05）. Such symptoms as aching loin and chest distress were strikingly improved in the treatment group（P0.05）. After treatment, the level of Scr was obviously increased in the treatment group and reduced in the control group（P0.05）, with a difference between the two groups（P0.05）. The contents of RBC, Hb, SBP and DBP were improved in the treatment group（P0.05）, with a difference between the two groups（P0.05）. There was a difference in EF in the treatment group between the pretreatment and posttreatment（P0.05）. Conclusion Combined ＂Shenxinning Decoction＂ and routine therapy is quite effective for heart disease following chronic renal insufficiency.

关 键 词：慢性肾功能不全 心脏病变 中西医结合疗法 肾心宁 

分 类 号：R692.5[医药卫生—泌尿科学] R541[医药卫生—外科学]