雌性棕色田鼠和昆明小鼠血象对急性低氧应答的比较研究  

Comparison on Responses to Acute Hypoxia in Blood Physiological Indices of Lasiopodomys mandarinus and Mus musculus

作　　者：刘彬[1] 王振龙[1] 路纪琪[1] 杨艳艳[1] 

机构地区：[1]郑州大学生物工程系生物多样性与生态学研究所,河南郑州450001

出　　处：《郑州大学学报（理学版）》2010年第4期106-110,共5页Journal of Zhengzhou University:Natural Science Edition

基　　金：国家重点基础研究发展计划;编号2007CB109106;郑州大学引进人才科研基金;郑州大学研究生科学研究基金

摘　　要：为探明雌性棕色田鼠在急性低氧处理下血象的变化,确定急性低氧对地下鼠的生理学作用,进而揭示地下鼠的血液系统对急性低氧的应答对策,在4 h急性低氧处理条件下,测定雌性棕色田鼠和昆明小鼠的血象指标并进行比较分析.结果显示,棕色田鼠和昆明小鼠的红细胞压积和红细胞体积在急性低氧处理下表现不同,但红细胞数均不受急性低氧处理的影响;棕色田鼠和昆明小鼠间血红蛋白含量相近且不受急性低氧处理的影响,两种鼠间平均血红蛋白浓度差异极显著,与红细胞体积变小有关;棕色田鼠的血小板数量显著低于昆明小鼠.研究结果表明,两种鼠均通过减小红细胞体积,增加血小板数量的方式应对急性低氧,并且棕色田鼠对低氧的耐受能力强于昆明小鼠.The blood physiological indices between Mandarin vole （Lasiopodornys mandarinus） and KM mouse （Mus musculus） are examed and compared under acute hypoxic treatment. Functional responses of blood system to acute hypoxia in subterranean and ground rodent species are determined. The results show that there are significant differences in HCT and MCV between Mandarin voles and KM mice under acute hypoxic treatment, while the difference in RBC is insig- nificant. Both in Mandarin voles and KM mice, the number of HGB is not influenced by hypoxia treatment, but significant difference is exhibited in MCHC, and the number of PLT in Mandarin voles is significantly less than that in KM mice. In general, the blood system of the two animals has similar responding patterns under acute hypoxic conditions, and Mandarin voles, compared to KM mice which derived from ground-lived ancestor, could effectively decrease the impact from hypoxic stress.

关 键 词：棕色田鼠 昆明小鼠 急性低氧 血液 雌性 适应 

分 类 号：Q461[生物学—生理学]