健脾消痞汤治疗功能性消化不良的胃动力学超声改变及其机制探讨  

Effect of the spleen-fortifying and stuffiness-dispersing therapy on gastric emptying in patients with functional dyspepsia by real-time ultrasonography

作　　者：高瑞凤[1] 邓世华[1] 陈丽[1] 朱晔[1] 娜仁高娃[1] 

机构地区：[1]广州医学院附属深圳沙井医院超声科,广东深圳518104

出　　处：《中国中西医结合消化杂志》2010年第5期300-302,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：深圳市宝安区科技局资助项目(2007082)

摘　　要：[目的]观察中药治疗对功能性消化不良(FD)患者的胃动力学变化,并探讨其作用机制。[方法]将40例FD患者用健脾消痞汤加减治疗1个疗程,观察对比治疗前后的胃动力学改变以及胃动素(MOT)、生长抑素(SS)的分泌情况。[结果]治疗后总有效率达97.5%;超声胃动力学指标:胃窦收缩幅度(△V)为(518.45±160.40)mm2、胃窦收缩频率(F)为(2.80±0.70)次/min、胃窦运动指数(MI)为(1 450.66±538.75)、胃窦半排空时间(T1/2)为(29.93±0.14)min、胃窦排空时间(T)为(46.35±13.82)min。△V较治疗前提高(P<0.05),F较治疗前增加(P<0.05)、MI较治疗前显著改善(P<0.01),T1/2、T均较治疗前明显缩短(P<0.01);患者空腹MOT较治疗前明显增高(P<0.01)、SS较治疗前明显减低(P<0.01)。[结论]健脾消痞汤治疗FD疗效满意,能够改善胃的排空功能,其作用机制可能是通过神经-体液调节各种胃肠激素的分泌所致。[Objective]To observe the effect of spleen-fortifying and stuffiness-dispersing therapy on gastric emptying in patients with functional dyspepsia（FD）.[Methods]The gastric emptying was evaluated by real-time ultrasonography and the plasma levels of motilin（MOT）and somatostatin（SS）were assayed by radioimmunoassay respectively in 40patients with FD before and after spleen-fortifying and stuffiness-dispersing therapy.[Results]The total effective rate was 97.5%.Gastric liquid emptying indexes after the therapy were significantly improved than those before the therapy.The plasma MOT level after the treatment was significantly higher（P 0.01）,and the plasma SS level were significantly lower than those of before the treatment（P 0.01）.[Conclusion]The therapy of spleen-fortifying and stuffiness-dispersing was an effective treatment for FD patients,by improving the gastric emptying endexes and regulating the gastrointestinal hormones.

关 键 词：消化不良 功能性 超声检查 胃动力学 

分 类 号：R723.1[医药卫生—儿科]