米氮平对伴抑郁障碍的冠心病患者的临床对照研究  

Mirtazapine Hydrochloride for Depression in Patients with Cardiovascular Diseases:A Randomized Controlled Trial

作　　者：左潇[1] 杨杰[1] 于得霞 徐建国[1] 

机构地区：[1]中国河北省唐山市第五医院,063004

出　　处：《中国健康心理学杂志》2010年第11期1309-1310,共2页China Journal of Health Psychology

摘　　要：目的探讨米氮平对抑郁障碍的冠心病患者的治疗效果及其临床意义。方法对48例伴抑郁障碍冠心病患者,进行8周的随机对照研究。实验组、对照组各24例。米氮平7.5～45m g/日,以BECK抑郁问卷(BD I)和汉密尔顿抑郁量表(HAM D)评定疗效,冠心病临床症状,血压、心电图监测冠心病缓解情况。结果米氮平抑郁症状的减轻明显优于对照组(P<0.05～0.01,根据BD I评分米氮平的显效率明显高于对照组(62.9%,33.3%,P<0.05),根据HAM D评分,米氮平的治愈率高于对照组(55.6%,37.1%,P<0.05)米氮平组冠心病相关症状的显效率比对照组更明显。结论米氮平能有效的减轻冠心病患者的抑郁症状,这种治疗更有利于冠心病的控制。Objective To investigate the prevalence of depression in patients with cardiovascular diseases and the effect of Mirtazapine hydrochloride.Methods A total of 48 patients with cardiovascular diseases and major depreesive disordr entered an 8-week randomized placedbo-control tril.Patients were given daily doses of Mirtazapine hydrochloride（up to 45mg/day）.The Beck Depression Inventory（BDI）and Hamilton Rating Scale for Depression（HAMD）were used to measure the severity of depression and to detemine the percentage of patients who achived substantial improvement or complete remission.Results The easement of depression who were treated by Mirtazapine hydrochloride was better than that in compared group（P〈0.05）.The efficiency of Mirtazapine hydrochloride in BDI was better than that in compareol group（62.9%,33.3%,P〈0.05）.Awording to the HAMD,the curedrate of mirtazapine hydrochloride was higher than that of compared group（55.6%,37.1%,P〈0.05）.The efficiency of cardiovascular treated by mirtazapine hydrochloride was better than that of compared group.Conclusion Doctors should pay attention to the prevalence of depression in patients with cardiovascular diseases.There is an apparently therapeutic effect after administering Mirtazapine hydrochloride.

关 键 词：冠心病 病历对照研究 抑郁 米氮平 

分 类 号：R541.4[医药卫生—心血管疾病]