罗红霉素颗粒剂的制备及生物利用度研究  

Preparation of Roxithromycin Granules and Study on Its Relative Bioavailability

作　　者：樊夏雷[1,2,3] 卓海通[1,2,3] 周炜 

机构地区：[1]江苏省药品检验所 [2]南京军区总医院 [3]中国药科大学

出　　处：《中国药科大学学报》1999年第2期94-96,共3页Journal of China Pharmaceutical University

摘　　要：研制了罗红霉素颗粒剂：以罗力得片为对照，采用微生物法进行了健康人体血药浓度测定，考察了罗红霉素颗粒剂的药动学特性。结果表明，罗红霉素颗粒剂与对照品为生物等效制剂。Roxithromycin granules were prepared. The pharmacokinetics and relative bioavailability of roxithromycin granules were investigated at the oral dose of 300 mg in 9 healthy volunteers.Drug concentrations in plasma were assayed by microbiology method.The results showed that roxithromycin granules were bioequivalent to Rulid tablets.

关 键 词：罗红霉素 药物动力学 生物利用度 颗粒剂 

分 类 号：R978.15[医药卫生—药品] R969.1[医药卫生—药学]