BPH组织中雄激素受体与转化生长因子-βⅠ型受体表达的相关性研究  

Expressions of androgen receptor and TGF β RI in benign prostatic hyperplasia

作　　者：吴刚[1,2] 那彦群[1,2] 孔祥田[1,2] 宓培[1,2] 夏同礼[1,2] 薛兆英[1,2] 郭应禄[1,2] 

机构地区：[1]北京医科大学第一临床医院泌尿外科 [2]北京医科大学泌尿外科研究所

出　　处：《中华泌尿外科杂志》1999年第5期302-305,共4页Chinese Journal of Urology

摘　　要：目的探讨雄激素受体（ＡＲ）与转化生长因子βⅠ型受体（ＴＧＦβＲⅠ）在良性前列腺增生（ＢＰＨ）组织中表达的意义及其相关性。方法采用免疫组化法研究两种受体在３１例ＢＰＨ和２２例正常前列腺标本中表达的状况。结果ＡＲ和ＴＧＦβＲⅠ在ＢＰＨ上皮、间质组织中的表达显著高于正常前列腺组织（Ｐ＜００５）；在ＢＰＨ间质组织中ＡＲ和ＴＧＦβＲⅠ的表达呈正相关（相关系数ｒ＝０３５８，Ｐ＜００５）。结论ＡＲ和ＴＧＦβＲⅠ在前列腺增生组织中表达增高，两者之间具有协同作用，提示两者在前列腺中的过表达可能参与了ＢＰＨ的发生和病理过程。Objective To investigate the expressions of androgen receptor (AR) and transforming growth factor β receptor Ⅰ (TGF β RI) in benign prostatic hyperplasia (BPH). Methods AR and TGF β RI expressions were detected in 31 human prostatic hyperplasia tissue specimens and in 22 normal prostatic tissues as controls. Results Positive expressions of AR and TGF β RI were much higher in the epithelial and mysenchymal of BPH than those in normal prostatic tissue ( P <0.05) and expression of AR was signigicantly associated with that of TGF β RI in stromal tissue of BPH ( r =0.358, P <0.05). Conclusions Expressions of AR and TGF β RI might play a role in the regulation of the growth of prostatic tissue and therefore might be a causative factor in prostatic hyperplasia.

关 键 词：前列腺增生 雄激素 受体 生长因子 

分 类 号：R697.32[医药卫生—泌尿科学]