雌激素影响大鼠随意皮瓣成活面积的试验性研究  

An experimental study of the effects of estrogen on random flap survival

作　　者：刘济远[1] 张富贵[1] 袁蒙姜[1] 唐休发[2] 

机构地区：[1]口腔疾病研究国家重点实验室 [2]四川大学华西口腔医院头颈肿瘤外科,四川成都610041

出　　处：《国际口腔医学杂志》2010年第6期634-636,共3页International Journal of Stomatology

基　　金：四川大学大学生创新实验计划基金资助项目(200891-415422080)

摘　　要：目的探讨雌激素对随意皮瓣成活面积的影响。方法将18只雌性SD大鼠随机分为给予雌激素100和300μg·kg-1组以及空白对照组,建立大鼠背部超长宽随意皮瓣模型,于试验组皮瓣远端皮下注射雌激素,于不同时间点检测3组随意皮瓣的微血管密度和存活面积。结果雌激素100μg·kg-1加随意皮瓣组皮瓣的微血管密度和成活面积高于雌激素300μg·kg-1加随意皮瓣组和对照组。结论适量的雌激素可增加随意皮瓣的微血管生成,提高随意皮瓣的成活面积。Objective The purpose of this experimental study is to explore the effects of estrogen in survival of random flaps. Methods Eighteen female SD rats were divided into three groups randomly,namely the 100 and 300 μg·kg^-1 groups,control group. The experimental models of ultra-length-and-width random flap on rats＇back were established,and the ones of experimental groups were injected with estrogen at the distal part of the flaps. The microvessel density and survival area of the random flaps in three groups were tested at different time points. Results The MVD and survival area of 100 μg·kg^-1 group are better than those of control group and 300 μg·kg^-1 group. Conclusion Proper dose of estrogen can promote angiogenesis of random flaps,and improve the survival area of random flaps.

关 键 词：雌激素 随意皮瓣 血管生成 成活面积 

分 类 号：R622[医药卫生—整形外科]