来氟米特对儿童难治性肾病综合征治疗观察  

The efficacy of leflunomide in children with refractory idiopathic nephrotic syndrome

作　　者：王自良[1] 刘鹏[1] 陈颖颖[1] 袁明良[1] 

机构地区：[1]山东省莱芜市人民医院肾内科,271100

出　　处：《中国现代医药杂志》2010年第11期54-56,共3页Modern Medicine Journal of China

摘　　要：目的观察来氟米特对儿童难治性肾病综合征治疗效果。方法对27例儿童难治性肾病综合征分为激素抵抗型9例,激素依赖型14例,频复型4例,分别给予来氟米特加激素治疗。结果治疗前后血白蛋白(P=0.0002)和24h尿蛋白(P<0.0001)明显改善,27例儿童难治性肾病综合征治疗后部分缓解7例(25.93%),完全缓解12例(44.44%),总缓解率70.37%。在微小病变和非微小病变之间(P=0.025)具有统计学意义。结论来氟米特对改善儿童难治性肾病综合征具有一定效果。Objective To observe the efficacy of leflunomide in the treatment of idiopathic refractory nephrotic syndrome.Methods 27 with refractory idiopathic nephrotic syndrome（14 with steroid-dependent nephrotic syndrome,9 with steroid-resistant nephrotic syndrome,4 with frequent-relapsing nephrotic syndrome） were enrolled in this study.Results Leflunomide plus prednisolone induced partial remission in 7 cases,complete remission in 12 cases.The total remission rate was 70.37%.The response to Leflunomide was significant differences between minimal change disease（MCD） and non-MCD（P= 0.025）.Conclusion Leflunomide may be effective in children with refractory idiopathic nephrotic syndrome.

关 键 词：来氟米特 肾病综合征 儿童 难治性 

分 类 号：R726.9[医药卫生—儿科]