米索前列醇用于终止晚期妊娠与引产的疗效观察  

Observation of the effect of misoprostol used to terminate late pregnancy and labor

作　　者：吴雪琴[1] 凌少云[1] 郑品端[1] 

机构地区：[1]广东省深圳市龙岗中心医院妇产科,518116

出　　处：《中国现代医药杂志》2010年第11期66-68,共3页Modern Medicine Journal of China

摘　　要：目的探讨米索前列醇用于终止晚期妊娠的合理剂量,并比较米索前列醇与缩宫素分别用于终止晚期妊娠的临床效果,为患者终止晚期妊娠和引产提供更好的治疗方案。方法将75例要终止晚期妊娠的患者分为小剂量组、中剂量组和大剂量组,应用不同剂量的米索前列醇后,比较三组的治疗效果和安全性,找到最合理的用药剂量。再将50例应用合理剂量米索前列醇终止晚期妊娠的患者与同期经缩宫素终止晚期妊娠的50例患者做比较,比较两组患者的引产成功率、促宫颈成熟情况、术后2h出血量、新生儿窒息和不良反应情况。结果小剂量组与中剂量组治疗效果和安全性最佳,大剂量组的安全性较差。米索前列醇终止晚期妊娠的临床疗效优于缩宫素组,两组各指标比较,差异均有统计学意义(P<0.05)。结论应用米索前列醇终止晚期妊娠的合理用药剂量为25～50μg,且应用米索前列醇终止晚期妊娠的临床疗效优于缩宫素。米索前列醇用于终止晚期妊娠安全有效。Objective To explore rational dose of misoprostol used to terminate late pregnancy and comparison of misoprostol and oxytocin for the clinical effect of late pregnancy terminated respectively.Provide better treatment for late pregnancy and labor.Methods 75 cases of late pregnancy were allocated into low dose group,dose group and high dose group,after the application of different dosage of misoprostol and comparison of therapeutic effect and safety of three groups,found the most reasonable medication dose.Compared 50 cases of late pregnancy patients and patients by oxytocin in late pregnancy terminated over the same period,compared two groups of patients with induced labor of success cervical ripening,amount of bleeding after 2h,neonatal asphyxia and adverse circumstances.Results Therapeutic effect and safety of low dose team was the best.Clinical effect of misoprostol group was better than oxytocin group,compared the indexes of two groups.The difference was statistically（P〈0.05）.Conclusion Application of rational drug dosage of misoprostol in the termination of late pregnancy is 25～50μg.Clinical curative effect of misoprostol in termination of late pregnancy is better than oxytocin.Misoprostol used to terminate late pregnancy is safe and effective.

关 键 词：米索前列醇 晚期妊娠 缩宫素 安全性 

分 类 号：R719.3[医药卫生—妇产科学]