动脉硬化性闭塞症患者肺炎衣原体DNA的表达  

Expression of chlamydia pneumoniae DNA in peripheral blood in patients with atherosclerosis obliterans

作　　者：朱巍[1] 沈焕[1] 赵丹丹[1] 赵铁柱[1] 

机构地区：[1]沈阳医学院附属沈洲医院血管外科,110002

出　　处：《中国综合临床》2010年第11期1160-1161,共2页Clinical Medicine of China

摘　　要：目的 从分子生物学角度探讨肺炎衣原体（Cpn）与动脉硬化性闭塞症（ASO）的相互关系.方法 随机选择60例ASO患者作为实验组,40名健康者作为健康对照组,采用聚合酶链反应（PCR）技术检测2组静脉血中Cpn的DNA表达情况.结果 ASO 患者静脉血中Cpn DNA阳性表达率为78.33%（47/60）,而健康对照组的阳性表达率为47.50%（19/40）,两者比较差异有统计学意义（P＜0.05）,并且随着ASO的病情发展其阳性表达率升高（Ⅰ期＋Ⅱ期为64.00%,Ⅲ期＋Ⅳ期为88.57%）.结论 Cpn的DNA表达与ASO的发生存在一定联系,其表达率同ASO的病程发展呈正相关.Objective To investigate the association between chlamydia pneumoniae（Cpn）and atherosclerosis obliterans（ASO）. Methods Sixty ASO patients and 40 healthy persons were selected,and their Cpn DNA expressions in venous blood determined by polymerase chain reaction（PCR）. Results The ASO patients had significantly higher positive expression rate of Cpn DNA than that of healthy persons（78. 33% vs. 47.50% ,P 〈0.05）. In all 60 cases the Cpn DNA expressions were positively correlated with the severity of ASO. Conclusions Cpn DNA expression closely relates with ASO severity,and it plays an important role in the ASO pathogenesis.

关 键 词：肺炎衣原体 动脉硬化性闲塞症 

分 类 号：R543[医药卫生—心血管疾病]