两种新的多羟基甾醇化合物分离与结构鉴定  

Isolation and Identification of Two New Polyhydroxysteroids

作　　者：张福勇[1] 王楠[1] 耿华伟[1] 廖小建[1] 徐石海[1] 

机构地区：[1]暨南大学化学系,广州510632

出　　处：《有机化学》2010年第11期1745-1748,共4页Chinese Journal of Organic Chemistry

基　　金：国家863基金(No.2006AA09Z408);国家自然科学基金(No.20772048)资助项目

摘　　要：采用现代分离手段,从采自中国南海硇洲岛的软珊瑚Chromonephthea sp.中分离纯化得到两种甾醇化合物,经过MS,IR,1H NMR,13C NMR(DEPT),HSQC,HMBC和NOE等光谱技术鉴定它们的结构为:24-甲基胆甾-5-烯-3β,12β,16β,20-四醇(1)和24-乙基胆甾-5-烯-3β,12β,16β,20-四醇(2),这两个化合物均为新化合物.肿瘤活性实验表明两种甾醇化合物显示微弱的细胞毒性.Two new polyhydroxysteroids have been isolated from Chromonephthea sp.collected from Naozhou Islands of the South China Sea.Their structures were established as 24-methylcholest-5-en-3β,12β,16β,20-tetraol（1） and 24-ethylcholest-5-en-3β,12β,16β,20-tetraol（2） by MS,IR,^1H NMR,^13C NMR（DEPT）,HSQC,HMBC and NOE techniques.Both of them are previously unknown compounds and showed weak cytotoxicity against the cancer cell lines.

关 键 词：软珊瑚 Chromonephthea sp. 多羟基甾醇 结构鉴定 

分 类 号：R284[医药卫生—中药学]