脓毒症患者血清白介素-6的表达及其意义  

Expression Level of Serum IL-6 in Septic Patients

作　　者：杨孟选 可妮 刘保池[2] 

机构地区：[1]河南省平顶山市第四人民医院普外科,467000 [2]复旦大学附属公共卫生临床中心外科

出　　处：《中国全科医学》2010年第32期3600-3602,共3页Chinese General Practice

摘　　要：目的探讨脓毒症患者血清白介素-6(IL-6)的表达及其意义。方法选取脓毒症患者99例(脓毒症组),根据有无多器官功能障碍综合征(MODS),分为MODS组16例和非MODS组83例,根据预后分为存活组94例和死亡组5例。同时选取体检正常者为对照组21例。采用酶联免疫吸附实验(ELISA)方法,检测不同时间段不同严重程度脓毒症患者血清IL-6水平。结果脓毒症组入院时及入院后第1、3、5、7天IL-6水平较对照组均明显升高,差异有统计学意义(P<0.05)。MODS组入院后第3、5、7、14天IL-6水平较非MODS组均明显升高,差异有统计学意义(P<0.05)。死亡组入院后第5、7、14天IL-6水平较存活组均明显升高,差异有统计学意义(P<0.05)。结论血清IL-6水平可以作为脓毒症和MODS判断严重程度和预后的一个敏感指标,在危重患者中IL-6可以持续长时间高水平的表达。Objective To investigate the expression level of serum IL-6 septic patients.Methods A total of 99 septic patients including 16 patients with multiple organ dysfunction syndrome（MODS）（MODS group）and 83 patients without MODS（non-MODS group）were included in this study.In addition,according to the outcomes,they were also divided into survival group（n=94）and death group（n=5）.In addition,21 normal controls were enrolled（control group）.The serum IL-6 level was detected by enzyme-linked immunosorbent assay（ELISA）.Results Serum IL-6 significantly increased in sepsis group than in control group at admission and 1,3,5,and 7 days after admission（all P〈0.05）.The expression of IL-6 level was significantly higher in MODS group than in non-MODS group 3,5,7,and 14 days after admission（all P〈0.05）,and was significantly higher in death group than in survival group 5,7,and 14 days after admission（all P〈0.05）.Conclusion IL-6 can maintain a persistent and high expression in the serum of critically ill patients.It can as a sensitive indicator for predicting the severity and prognosis of sepsis and MODS.

关 键 词：脓毒症 多器官功能衰竭 白介素-6 

分 类 号：R515.3[医药卫生—内科学]