冠状动脉慢血流临床相关因素和冠状动脉解剖因素分析  

Analysis of Clinical and Anatomical Factors in Coronary Slow Flow Phenomenon

作　　者：耿丽丽[1] 李军[1] 刘百球[1] 王晓[1] 刘新民[1] 乔岩[1] 罗太阳[1] 贾长琪[1] 聂绍平[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科2病房,北京市100029

出　　处：《中国全科医学》2010年第32期3631-3634,共4页Chinese General Practice

摘　　要：目的探讨影响冠状动脉慢血流现象的临床因素和冠状动脉解剖因素。方法入选2008年3月—2009年9月因怀疑冠心病于我科行冠状动脉造影检查,结果示冠状动脉无明显狭窄且存在冠状动脉慢血流现象的患者95例为慢血流组,同期冠状动脉无明显狭窄且血流正常的患者100例为对照组。采用校正的TIMI血流计帧法(correctedTI-MIframecount,CTFC)检测,其中CTFC值>27诊断为冠状动脉慢血流。记录相关的临床资料进行多元Logistic回归分析。结果两组平均血流帧数比较,差异有统计学意义(P<0.01)。两组患者男性比例及BMI比较,差异均有统计学意义(P<0.05);两组白介素-6(IL-6)和B型钠尿肽(BNP)水平比较,差异均有统计学意义(P<0.05);而其他实验室检查指标比较,差异均无统计学意义(P>0.05)。两组冠状动脉扭曲系数和冠状动脉远端主要血管分支数比较,差异均有统计学意义(P<0.05)。多元Logistic回归分析结果示,男性、BMI、IL-6、冠状动脉扭曲系数和冠状动脉远端分支数与冠状动脉慢血流现象相关(P<0.05)。结论炎性因子和冠状动脉解剖因素与冠状动脉慢血流现象相关,其可能参与冠状动脉慢血流的发病机制。Objective To analyze retrospectively the clinical and anatomical factors related to coronary slow flow phenomenon（CSFP）.Methods Ninety-five CSFP patients diagnosed by coronary angiography from March 2008 to September 2009 were divided into CSFP group,and 100 with normal CSFP into control group.Corrected TIMI frame count（CTFC）was used to document coronary flow rates.Multiple logistic regression analysis was performed on recorded clinical data.Results There was significant difference in frame count between 2 groups（P〈0.01）,in proportion of males and BMI（P〈0.05）,in interleukin-6（IL-6）and B-type natriuretic peptide（BNP）（P〈0.05）,and in arterial kinking coefficient and number of main branches of distal coronary artery（P〈0.05）,but there was not in other laboratory indicators（P〈0.05）.Multiple Logistic regression analysis showed that males,BMI,IL-6,arterial kinking coefficient and distal coronary artery were correlated with CSFP（P〈0.05）.Conclusion Factors of Inflammatory and coronary artery anatomy,correlated with CSFP,may be involved in the pathogenesis of CSFP.

关 键 词：冠状动脉慢血流现象 炎症 冠状动脉 解剖 

分 类 号：R541.4[医药卫生—心血管疾病]