以SDF-1/CXCR4为靶点治疗疾病的研究进展  

SDF-1 /CXCR4 as Therapeutic Targets

作　　者：杨文博[1] 孔佩艳[2] 

机构地区：[1]山东潍坊解放军第89医院血液科,山东潍坊261021 [2]重庆第三军医大学新桥医院血液科,重庆400037

出　　处：《医学综述》2010年第21期3230-3232,共3页Medical Recapitulate

摘　　要：SDF-1/CXCR4是一对重要的趋化因子配体/受体,与肿瘤、免疫缺陷病毒感染、多种炎症等病理状态相关。以SDF-1/CXCR4轴为靶点治疗相关疾病成为人们研究的热点。阻断CXCR4受体可抑制肿瘤细胞的转移及增殖、防护人免疫缺陷病毒感染、减轻炎性反应。现就以SDF-1/CXCR4轴为靶点治疗相关疾病的研究进展予以综述。SDF-1 /CXCR4 is a pair of very important ligand/receptor,which plays a concernful role in the pathological process of tumour,infection HIV,and inflammation. There has been increasing studies on SDF-1 /CXCR4 as therapeutic target. The studies concluded that the modulation of SDF-1 /CXCR4 axis could restrain the migration and proliferation of tumor,prevent infection of HIV,and alleviate the inflammation.

关 键 词：基质细胞衍生因子1 受体CXCR4 靶点 

分 类 号：R392.1[医药卫生—免疫学]