树突状细胞在抗肿瘤免疫中的研究进展  

Advances of Dendritic Cell in Anti-tumor Immunoreaction

作　　者：张宇[1] 崔晓靓[1] 段鹍[2] 宋晓凯[1] 

机构地区：[1]南京农业大学动物医学院,南京210095 [2]南京农业大学食品科学技术学院,南京210095

出　　处：《医学综述》2010年第21期3262-3264,共3页Medical Recapitulate

摘　　要：树突状细胞(DC)是目前已知的体内功能最强,且惟一能激活静息型T细胞的抗原递呈细胞,它能有效摄取加工肿瘤抗原,分泌多种细胞因子,活化免疫应答,在机体抗肿瘤免疫中发挥重要作用。发挥DC的功能活性,增加肿瘤抗原免疫原性,有助于诱导机体有效的抗肿瘤免疫反应。目前,以DC为基础的肿瘤免疫治疗已取得较大进展,展示出良好的临床应用前景。Dendritic cell（ DC） is the strongest antigen-presenting cell in human body. It has some special functions such as initiating T cells and inducing immune responses. Extensive studies show that DC plays an important role in the process of anti-tumor immune response. In recent years,the practice of tumor immunotherapy by DC has attracted much attention and achieved great progress. This article reviews DC regarding its biological properties,immune mechanism and applications in anti-tumor immunoreaction.

关 键 词：树突状细胞 肿瘤 免疫疗法 

分 类 号：R329.21[医药卫生—人体解剖和组织胚胎学]