急性百草枯中毒患者外周血WBC计数CRP浓度变化及意义  

The Changes and Clinical Significance of WBC Count and CRP with Acute Paraquat Poisoning

作　　者：张兴国[1] 谷燕[1] 刘尊齐[1] 王海石[1] 周志俊[2] 

机构地区：[1]山东大学附属省立医院,山东济南250021 [2]复旦大学,上海200010

出　　处：《河北医学》2010年第11期1319-1321,共3页Hebei Medicine

基　　金：国家科技支撑计划(2006BAI06B01)

摘　　要：目的:探讨急性百草枯中毒患者外周血白细胞计数、血清C反应蛋白浓度与预后的关系。方法:急性百草枯中毒患者101例,分为存活组和死亡组,以住院期间死亡为观察终点,两组患者分别于中毒后第1天、第3天及第7天检测外周血白细胞计数及血清C反应蛋白浓度,两组间进行统计学分析比较。结果:死亡组于中毒后第1天外周血WBC计数明显高于存活组(P<0.001);死亡组于中毒后第1天、第7天血清CRP浓度均明显高于存活组(P<0.01和P<0.05)。结论:外周血白细胞计数及血清C反应蛋白浓度是判断急性百草枯中毒病情严重程度及预后的可靠指标,且C反应蛋白浓度更敏感。Objective： To investigate the relationship bewteen the white blood cell（WBC）count,the levels of blood C-response protein（CRP） and the prognosis of patients with acute paraquat poisoning.Method： 101 patients were divided into two groups,the death group and the survival group according to death in hospital.On the 1st day,the 3rd day and the 7th day after poison,WBC in patients’blood and CRP were detected,the data were analyzed.Result： After poison on the 1st day,WBC of the death group was higher than the survival group obviously（P〈0.001）.and after poison on the 1st day,the 7th day,blood CRP of the death group was higher than that in the survival group obviously（P〈0.01 and P〈0.05 respectively）.Conclusion： WBC and blood CRP might be the reliable indicators of the severity and the prognosis of acute paraquat poisoning,and also blood CRP was more sensitive.

关 键 词：百草枯 中 毒 白细胞 C反应蛋白 

分 类 号：R595.4[医药卫生—内科学]