依那普利联合螺内酯对慢性心力衰竭患者氧化应激状态的影响  

Influence of Spironolactone Combined with Enalapril on Oxidative Stess Status in Chronic Heart Failure

作　　者：杨晴[1] 

机构地区：[1]湖北省黄冈市红安县人民医院内一科,湖北红安438400

出　　处：《中国现代医生》2010年第33期62-64,共3页China Modern Doctor

摘　　要：目的观察依那普利联合螺内酯对慢性心力衰竭的疗效及对患者个体氧化应激状态的影响。方法将70例慢性心力衰竭患者纳入研究中,随机分为治疗组和对照组,两组均给予常规基础治疗,治疗组同时加用神经节苷脂和纳洛酮。结果慢性心衰个体应用不同方案治疗后,治疗组患者有效率为91.4%,对照组患者有效率为71.4%,治疗组疗效显著好于对照组(P<0.05)。同时治疗前后患者MDA明显降低;GPx、AOA则显著升高(P<0.05)。结论依那普利联合螺内酯治疗,可使患者体内脂质过氧化水平显著降低,抗氧化水平回升,通过缓解氧化应激损伤,控制病情,获得良好疗效。Objective To observe the efficacy of Spironolactone combined with Enalapril in the treatment of chronic heart failure and the influence of these drugs on its oxidative stress status. Methods Total 70 cases of chronic heart failure were randomly divided into two groups. Both groups were given conventional treatment and Spironolactone and Enalapril were added to the treatment group. Results The total effective rate of the treatment group was 91.4% and that of the control group was 71.4%, with a significant difference between the two groups（P〈0.05）. In the treatment group, the MDA was significantly decreased after treatment（P〈0.05）, while the GPx and AOA were significantly increased after treatment（P〈0.05）. Conclusion Spironolactone combined with Enalapril is an effective method in the treatment of chronic heart failure and the oxidative stress can achieve complete remission.

关 键 词：慢性心力衰竭 螺内酯 依那普利 氧化应激 

分 类 号：R541.6[医药卫生—心血管疾病]