龙胆泻肝丸物质组释放动力学特征研究  

Materiomic release kinetics of Longdan Xiegan Pill

作　　者：郭桢[1,2] 凌昳[1,2] 张继稳 葛卫红[1] 石森林[1] 

机构地区：[1]浙江中医药大学药学院,浙江杭州310053 [2]中国科学院上海药物研究所药物释放系统研究中心,上海201203

出　　处：《中草药》2010年第11期1806-1808,共3页Chinese Traditional and Herbal Drugs

基　　金：国家高技术研究发展计划(863计划)资助项目(2006AA02Z336);国家科技支撑计划项目(2006BA1098B08-08);中国科学院上海药物研究所新药团队基础研究项目(07G603F015)

摘　　要：目的研究龙胆泻肝丸的物质组释放动力学特征。方法按《中国药典》桨法100 r/min测定龙胆泻肝丸的释放度,运用紫外吸收光谱法结合Kalman滤波法对龙胆泻肝丸物质组进行定量,并绘制释放曲线,获得龙胆泻肝丸的物质组释放动力学特征和多维释放特征。结果 龙胆泻肝丸的缓释特征明显,动力学特征符合Weibull和Higuchi释放模型。结论龙胆泻肝丸的释放机制可能属于骨架溶蚀型,提示传统丸剂具有明显的缓释特征。Objective To study materiomic release kinetics of Longdan Xiegan Pill.Methods The materiomics release kinetics,the release profiles,and the multidimensional release characteristic of Longdan Xiegan Pill were determined by the paddle method with a rotate speed at 100 r/min in Chinese Pharmacopia,and the materiome was quantified by UV-vis combined Kalman filter method.Results Longdan Xiegan Pill behaved typical sustained release profile which was consistent with Weibull and Higuchi release models.Conclusion The sustained release profile of Longdan Xiegan Pill is depicted quantitatively by materiomic release dynamics in this paper,which demonstrates the obvious sustained release characteristic of the traditional pills.

关 键 词：龙胆泻肝丸 中药物质组 释放动力学 紫外吸收光谱法 

分 类 号：R286.02[医药卫生—中药学]