2-(2,6-二烷氧基苯基)苯并呋喃衍生物的合成  

Synthesis of 2-(2,6-Dialkoxyphenyl)-benzo[b]furan Derivatives

作　　者：亓金萍[1] 曹德榕[1] 

机构地区：[1]华南理工大学化学与化工学院,广州510640

出　　处：《化学学报》2010年第19期2019-2023,共5页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20872038);广东省教育部产学研结合(No.粤财教[2008]258号)资助项目

摘　　要：以焦性没食子酸、4-羟基苯甲醛和酚为原料,以邻碘代苯酚与苯乙炔衍生物的Sonogashira偶联及其连串化反应生成苯并呋喃环为关键步骤,设计合成了一系列2-(2',6'-二烷氧基苯基)苯并呋喃衍生物,并对产物进行了1HNMR,13CNMR,MS等表征.Starting from pyrogallic acid, 3,4-dimethoxyphenol, 4-hydroxybenzaldehyde and phenols, a series of 2-（2＇,6＇-dialkoxyphenyl）-benzo[b]furan derivatives were designed and synthesized. The Sonogashira cross-coupling of o-iodophenol and aryl acetykenes was the key step of the synthetic route. All the new benzo[b]furan derivatives were confirmed by 1H NMR, 13C NMR and MS techniques.

关 键 词：Sonogashira偶联 2-苯基苯并呋喃 苯并呋喃 Lespedezavirgatol 

分 类 号：TQ251.1[化学工程—有机化工]