难溶性药物注射给药系统的研究进展  

Advances for Parenteral Delivery of Slightly Water-soluble Drugs

作　　者：邓家华[1] 蔡伟惠[1] 金方[1] 

机构地区：[1]上海医药工业研究院,创新药物与制药工艺国家重点实验室,上海200437

出　　处：《中国医药工业杂志》2010年第11期856-863,共8页Chinese Journal of Pharmaceuticals

基　　金：上海市优秀学科带头人计划(08XD14225);上海市纳米科技专项(0952nm04500);国家“重大新药创制”科技重大专项资助(2009ZX09301-007)

摘　　要：由于高通量筛选技术在药物开发上的广泛应用,涌现了越来越多水难溶性的新化合物。注射剂在临床治疗中发挥着重要的作用,但水溶性低却成了这些化合物开发成注射剂的一个主要难题。本文综述了微乳、亚微乳、前药、环糊精包合物、纳米混悬剂和聚合物胶束系统等在难溶性药物注射给药方面的应用,以期能通过比较各给药系统的优缺点,为产品的开发提供思路。An increasing number of slightly water-soluble new chemical compounds have been generated,with the widespread application of high-throughput screening technology in drug discovery.Injections are of great importance in clinical therapy.However,their poor solubility represents a major challenge for formulation of these compounds in parenteral drug delivery.This paper reviews the application for parenteral delivery systems of slightly water-soluble drugs,including microemulsions,submicron emulsions,prodrugs,nanosuspensions,cyclodextrin inclusion compounds and polymeric micelles.We are trying to provide some ideas for product development by comparing both advantages and disadvantages of various systems.

关 键 词：微乳 亚微乳 前药 环糊精包合物 纳米混悬剂 聚合物胶束 难溶性药物 综述 

分 类 号：R944.9[医药卫生—药剂学]