复宫宁对子宫内膜异位症大鼠异位内膜雌、孕激素受体表达和动情周期的影响  

Effects of Fugongning on the Expression of ER,PR of Ectopic Endometrium and Estrum in Endometriosis Model Rats

作　　者：乔玉丹[1] 张晓春[2] 周志愉[1] 施旻[1] 肖纯[1] 

机构地区：[1]江西中医学院,江西南昌330004 [2]井冈山大学医学院,江西吉安343009

出　　处：《时珍国医国药》2010年第11期2743-2744,共2页Lishizhen Medicine and Materia Medica Research

基　　金：江西省自然科学基金(No.0040008);江西省卫生厅科技计划项目(No.20092051)

摘　　要：目的探讨复宫宁治疗子宫内膜异位症(内异症)的作用机理。方法建立大鼠内异症动物模型,采用免疫组化SP法检测异位内膜雌激素受体(ER)、孕激素受体(PR)的表达和阴道涂片法观察动情周期。结果复宫宁高、中、低剂量组能显著降低异位内膜ER、PR的表达并显著改善内异症大鼠的动情周期(P<0.05)。结论复宫宁可能通过抑制异位内膜细胞ER、PR的合成而发挥治疗作用,并具有整体调节作用。Objective To explore the mechanism of Fugongning（FGN） in treatment of endometriosis.Methods The rat model of endometriosis was established,the expression of ER,PR in each group of ectopic endometrium was observed by immunohistochemical method.Estrum was observed by vagina smear method.Results Alldoses of FGN could obviously lower the expression of ER and PR in ectopic endometrium of endometriosis model rats and ameliorate their estrum（P0.05）.Conclusion FGN can limit its growth of ectopic endometrium by lowering the expression of ER and PR in ectopic endometrium,and can adjust the rat whole.

关 键 词：子宫内膜异位症 复宫宁 大鼠 雌激素受体 孕激素受体 免疫组织化学法 

分 类 号：R285.5[医药卫生—中药学]