PNIPAAm包覆MCM-41复合材料的合成与温度敏感释药  

Synthesis and temperature controlled drug release performance of PNIPAAm coating for MCM-41

作　　者：张光辉[1] 曹渊[1] 王晓[1] 夏之宁[1] 徐彦芹[1] 代薇薇[1] 

机构地区：[1]重庆大学化学化工学院,重庆400044

出　　处：《重庆大学学报（自然科学版）》2010年第11期96-101,共6页Journal of Chongqing University

基　　金：国家自然科学基金资助项目(20775096);科技部国际合作项目(2006DFA43520);中国博士后科学基金资助项目(20080440696)

摘　　要：以3-氨丙基乙氧基硅烷(3-aminopro pyltriethoxyl silicane,APS)为偶联剂,用微波法合成了氨丙基修饰的MCM-41(amino-functionalzed mesoporous MCM-41,AP-MCM-41),将其与N-异丙基丙烯酸胺(N-isopropylacry lamide,NIPAAm)原位聚合制备了一种新型的温度敏感性复合材料AP-MCM-41/PNIPAAm,使用氮吸附/脱附,X射线衍射、Fourier红外、热重分析等对材料进行表征。结果表明,成功制备了一种新型复合材料,并有良好的温度敏感性。选取氢氯噻嗪为模型药物,用浸渍法组装,研究了不同温度下材料的释药行为,结果显示,当温度高于复合材料的相转变温度(Lower critical solution temperature,LCST)时复合材料失水收缩阻碍了药物的释放,低于LCST时由于材料亲水性增强使释药量明显增加。Amino-functionalzed mesoporous MCM-41（AP-MCM-41） is synthesized by the microwave method,using 3-aminopropyltriethoxylsilicane（APTES） as the coupling agent,and through polymerizing AP-MCM-41 with N-isopropylacrylamide（NIPAAm）,a typical composite material which is sensitive to temperature is synthesized.By low-temperature N2 absorption-desorption,X-ray diffraction,Fourier transform infrated spectroscopy and thermogravimetry analysis etc.,it＇s found that the new composite material possesses temperature sensitivity.Selecting hydrochlorothiazide as a model drug and using the impregnation method,its release behavior under different temperatures are studied.The results show that when the temperature is higher than the lower critical solution temperature（LCST）,the hydrophobicity of the material that blocks the releasing of the drug will be formed,and when the temperature is lower than the LCST,the release amount will increase significantly due to the hydrophilicity of the material.

关 键 词：介孔材料 聚N-异丙基丙烯酸胺 温度控制 药物释放 

分 类 号：O614[理学—无机化学]