复方甘露醇注射液组方的筛选  

Selecting the Best Preparation or Compound Mannitol Injections

作　　者：王丽娟[1] 李涛[1] 陈咏梅 朱坤杰 李清漪 孟文芳 孙旭光[1] 宋本海[1] 

机构地区：[1]齐齐哈尔市第一医院

出　　处：《齐齐哈尔医学院学报》1999年第3期207-209,共3页Journal of Qiqihar Medical University

摘　　要：采用家兔颈内动脉注射橄榄油致急性脑水肿的方法制作家兔急性脑水肿模型，观察了不同组份的复方甘露醇注射液与20％甘露醇注射液对家兔急性脑水肿的作用。结果显示：各级复方甘露醇注射液均有明显的脱水与利尿作用（与20％甘露醇比较，P＞0.05；与0.09％氯化钠比较，P＜0．05），并提示组方Ⅰ、Ⅱ和Ⅲ脱水作用较好，组方Ⅲ的利尿作用最强。Injecting the olive oil into one side internal carotid artery, it produced the acute experimentalbrain edema in rabbits. Then observed and compared the effect of different compound mannitol injections with20% mannitol on acute experimental brain edema in rabbits. The results showned the deprivation and diuresis ofevery comPOund mannitol injection were abvious(comparing with 20% mannitol, P > 0. 05; comparing with 0.9 % ndium chloride, P < 0.05 ),and the results suggested that the compoLind edtol - I IIand IIIwere better.

关 键 词：脑水肿 甘露醇 复方甘露醇 组方 筛选 

分 类 号：R942[医药卫生—药剂学] R983.1[医药卫生—药学]