白桦酸类化合物的结构修饰与生物活性研究进展  

Advances in the study of structural modifications and biological activities of betulinic acids

作　　者：蓝平[1] 张冬梅[1] 陈卫民[1] 叶文才[1] 

机构地区：[1]暨南大学药学院,广东省中药药效物质基础及创新药物研究重点实验室,广东广州510632

出　　处：《药学学报》2010年第11期1339-1345,共7页Acta Pharmaceutica Sinica

基　　金：广东省自然科学基金资助项目(9151063201000053)

摘　　要：白桦酸类化合物属于羽扇豆烷型五环三萜化合物,主要分布在桦木科植物中,其良好的抗HIV、抗肿瘤活性正受到越来越多的关注。天然存在的白桦酸类化合物主要有白桦酸、23-羟基白桦酸及白桦素等。文献报道了不同白桦酸类化合物的结构修饰研究,并获得了一些具有较强生物活性的衍生物。本文主要对白桦酸类化合物的结构修饰及抗HIV、抗肿瘤作用研究进展进行综述。Betulinic acids are lupine-type pentacyclic triterpenoid saponins commonly found in some plants of Betulaceae family,especially in the bark of betula alba（birch）.The potent anti-HIV and anti-tumor activities of betulinic acids have been greatly concerned.The natural betulinic acids include betulinic acid,23-hydroxy betulinic acid,betulin and so on.Some investigations on the structural modifications of betulinic acids were carried out,and many derivatives with excellent biological activity have been obtained nowadays.In this paper,the research advances of the structural modification of betulinic acids,as well as their anti-HIV and anti-tumor activities are reviewed.

关 键 词：白桦酸 23-羟基白桦酸 白桦素 结构修饰 抗HIV活性 抗肿瘤活性 

分 类 号：R284[医药卫生—中药学]