基于物质粗糙集理论的中药复方缓释制剂“总量”释放动力学评价模式  

"Total amount" release kinetics evaluation of traditional Chinese medicine sustained-release preparations based on material rough set theory

作　　者：岳鹏飞[1] 郑琴[1] 朱根华[1] 伍振峰[1] 胡鹏翼[1] 杨明[1] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《药学学报》2010年第11期1354-1360,共7页Acta Pharmaceutica Sinica

基　　金："十一五重大新药创制专项"中药复方释药系统技术平台项目(2009ZX09310-005);"十一五"科技支撑计划项目(2006BA109B08-1);江西省卫生厅中医药科研项目(2009A061;2009A059)

摘　　要：中药复方缓控释制剂体外释放动力学评价研究是中药制剂现代化研究中不可分割的重要组成部分,在现代复方中药研发中发挥着重要作用,但目前尚缺乏符合中药自身多成分多靶点特征的释放动力学评价方法。本文在回顾分析既有评价模式利弊的基础上,借鉴粗糙集理论,提出基于物质粗糙集理论的中药复方缓释制剂"总量"释放动力学评价模式,评价释放过程中复方中药制剂的化学物质"总量"动态变化特征,以期"抛砖引玉",促进中药复方缓控释制剂释放行为评价方法的发展。The release kinetics research of sustained-release formulations of traditional Chinese medicines（TCM） is an inalienable part of the chain of TCM modernization,which plays an important role in the development of modern compound TCM preparation.However,the research method or pattern in line with the specific characteristics of TCM,i.e.,multi-component and multi-target,is still lacking.On the basis of material rough set theory,this paper reviewed the advantages and disadvantages of the existing evaluation patterns and methods,a tentative idea about the ＂total amount＂ release characteristics evaluation on TCM compound sustained-release preparation has suggested so as to evaluate the release kinetics and to promote the development of evaluation methodology on TCM sustained-release preparations.

关 键 词：粗糙集理论 “总量”释放动力学 多元校正计量 效应计量 中药缓释制剂 

分 类 号：R943[医药卫生—药剂学]