The Achilles heel of γ-secretase： can we contain Alzheimer＇s disease by reducing synthesis of β-amyloid？  

作　　者：Alexei VERKHRATSKY 

机构地区：[1]Faculty of Life Sciences, The University of Man- chester, Manchester, UK [2]KERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain [3]Department of Neurosciences, University of the Basque Country UPV/EHU, 48940, Leioa, Spain

出　　处：《Acta Pharmacologica Sinica》2010年第11期1407-1408,共2页中国药理学报（英文版）

摘　　要：Alzheimer＇s disease is the ultimate .scourge of mankind that haunts the ageing population and increas- ingly becomes the major health and social problem faced by our society. Alzheimer＇s disease （AD）, described by Alois Alzheimer as dementia praecox （and named Alzheimer＇s disease by Emil Kraepelin several years later）, is a severe neurodegenerative pathology associated with specific histopathological markers represented by focal extra- cellular deposits of fibrillar β-amyloid （also called neuritic or senile plaques） in the parenchyma of the brain and in the wails of blood vessels,Alzheimer＇s disease is the ultimate .scourge of mankind that haunts the ageing population and increas- ingly becomes the major health and social problem faced by our society. Alzheimer＇s disease （AD）, described by Alois Alzheimer as dementia praecox （and named Alzheimer＇s disease by Emil Kraepelin several years later）, is a severe neurodegenerative pathology associated with specific histopathological markers represented by focal extra- cellular deposits of fibrillar β-amyloid （also called neuritic or senile plaques） in the parenchyma of the brain and in the wails of blood vessels,

分 类 号：Q517[生物学—生物化学] TQ463.54[化学工程—制药化工]