磷烧伤的体内^(31)P MRS研究  

In Vivo ^(31)P MRS Studies of Phosphorus Burns

作　　者：田建广[1] 阮仕荣 

机构地区：[1]军事医学科学院国家生物医学分析中心,100850 [2]张家口市第二五一医院,075000

出　　处：《中国烧伤创疡杂志》1999年第2期4-7,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的：为了解黄磷在体内的吸收、转运和分布情况，并做出定量估计。方法：建立磷烧伤动物模型，利用表面线圈31PNMR研究小鼠背部磷烧伤时创伤面及肝脏部位民PO4和P4分子的变化。结果；表明磷烧伤后，创伤面产生大量已PO4而且肝脏H3PO4也升高；燃烧不完全剩余的少量磷以分子状态被创面组织吸收，并可转运到肝脏。结论：核磁共振（NMR）是无损伤、无破坏性可连续进行测定的技术，表面线囫31PNMR可选择性地测定活体动物或人体局部组织中所含磷化物量的变化。When phosphorus burn occurs, phosphorism is one of the main causes of death. We used surface coil 31P NMR to study the changes of H3PO4 and P4 content at the position of burn wound and in the liver of the mice which had been burned by phosphorus on back. The results showed that after phosphorus burn, much H3PO4 appeared at the burn wound and H3PO4 level in the liver increased. Residual phosphorus could be absorbed quickly by the tissue and transferred to the liver.

关 键 词：磷烧伤 磷31 NMR 创伤面 肝脏 体内分布 

分 类 号：R644.02[医药卫生—外科学]