微小RNA与心肌缺血  

MicroRNA and myocardial ischemia

作　　者：方际[1] 袁文俊[1] 林丽[1] 

机构地区：[1]第二军医大学生理教研室,上海医学硕士200433

出　　处：《医学研究生学报》2010年第10期1085-1089,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(30670760;30870906);上海市浦江人才计划项目(08PJ14001)

摘　　要：微小RNA(MicroRNA,miRNA)是一类具有转录后调节活性的内源性小分子RNA,能按照碱基互补配对原则与靶信使RNA(messenger RNA,mRNA)的3′端非编码区(3′-untranslated region,3′-UTR)序列相互识别,引起靶mRNA的降解和(或)翻译抑制。生物信息学分析显示,1个miRNA分子的潜在靶mRNA可能有上百个,提示了miRNA生物学功能的多样性与复杂性。目前研究表明,miRNA与心血管疾病密切相关。在心肌梗死、缺血性心律失常、心肌梗死后纤维化、血管新生等与心肌缺血相关的病理过程中,miRNA的表达发生变化,并具有重要的功能意义,文中对该领域的研究进展进行综述。MicroRNA（miRNA） are a class of endogenous small RNA involved in post-transcriptional regulation.Based on the base-pairing principle,miRNA bind to complementary sequences that are usually located in the 3′-untranslated region（3′-UTR） of target mRNA,then trigger mRNA cleavage and/or translational repression.Bioinformational analyses predicted that one miRNA can target hundreds of mRNA,indicating the multiplicity of miRNA function.Recent research demonstrated a close correlation between miRNA and cardiovascular diseases.Changes of miRNA expression were showed to play pivotal roles in the pathologic processes including myocardial ischemia,ischemic arrhythmia and post-ischemic vascular genesis.The involvement of miRNA in ischemic heart disease was summarized in this review.

关 键 词：微小RNA 心肌缺血 心室重塑 心律失常 血管新生 

分 类 号：Q522[生物学—生物化学]