急性颅脑损伤患者垂体前叶功能紊乱的危险因素分析  

Analysis of risk factors related to antepituitary dysfunction in patients with traumatic brain injury

作　　者：车彦军[1] 张智民[1] 陈兴[1] 齐心[1] 潘恩裕[1] 陈鹏[1] 夏智源[1] 骆杰民[1] 李震[1] 武宏杰[1] 

机构地区：[1]靖江市人民医院神经外科,江苏214500

出　　处：《中国临床神经外科杂志》2010年第11期664-667,共4页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨急性颅脑损伤（TBI）患者垂体前叶功能紊乱的危险因素。方法符合入选标准的82例TBI患者,于伤后~3 d采取静脉血,检测垂体激素水平,与正常值作对照;同时将对垂体激素分泌有影响的14项可能因素进行统计学分析。结入选的TBI患者中,82.93%发生垂体前叶激素分泌紊乱,经Logistic回归分析表明,GCS评分3~8分和中线结构移位≥0.5 cmTBI患者伤后前垂体功能紊乱的危险因素（P〈0.05）。结论 TBI后垂体前叶激素分泌紊乱发生率极高,脑损伤程度和中线结构位是发生TBI后垂体前叶激素分泌紊乱的重要危险因素。Objective To explore the antepituitary dysfunction and risk factors related to it in the patients with traumatic braininjury （TBI）. Methods The plasma levels of the antepituitary hormones were detected 1, 2 and 3 days after the injury in 82 patients withTBI. The factors possibly related to the secretion of antepituitary hormones were analyzed. Results The rate of antepituitary dysfunctionwas 82.93%（68/82） in 82 patients with TBI. Logistic regression analysis showed that GCS≤8 and medline shift≥0.5 cm were riskfactors resulting in the antepituitary dysfunction in the patients with TBI （P0.05）. Conclusions The rate of antepituitary dysfunction ishigh within 3 days after TBI. The degree of TBI and medline shift are significantly related to the antepituitary dysfunction in the patientswith TBI.

关 键 词：急性颅脑损伤 垂体 危险因素 功能紊乱 

分 类 号：R651.15[医药卫生—外科学] R584[医药卫生—临床医学]