Modulation of long-term potentiation in the hippocampus by pharmacological approach:A novel strategy for the development of cognitive enhancers  

作　　者：YANG YuanJian WU PengFei WANG Fang CHEN Jian Guo 

机构地区：[1]Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan 430030, China [3]Institutes of Biomedicine and Drug Discovery, Huazhong University of Science and Technology, Wuhan 430030, China

出　　处：《Chinese Science Bulletin》2010年第30期3374-3382,共9页

基　　金：supported by the National Basic Research Program of China (2007CB507404);the Chang Jiang Scholar Program of the Ministry of Education of China,the Key Project of National Natural Science Foundation of China (30930104);the Program for New Century Excellent Talents in Universities of China (NCET-08-0225)

摘　　要：Learning and memory not only provide the foundations of cognition, but are also closely related to sensory and motor function. Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are accompanied by deficits in synaptic function and cognition to varying degrees. The discovery of long-term potentiation (LTP) of hippocampal synaptic transmission, which has been recognized as a classical model of learning and memory at the cellular level, has spurred substantial progress in the development of cognitive enhancers in the past 20 years. Following intensive investigations into LTP, a variety of compounds and biologically active substances have been found to modulate hippocampal LTP via numerous molecular mechanisms including regulating presynaptic neurotransmitter release, postsynaptic N-methyl D-aspartate (NMDA) receptor activity, postsynaptic signal transduction and gene transcription. This review focuses on the progress of investigations into the overarching mechanisms of LTP, the drugs modulating LTP and prospects for the development of new drugs for treating cognitive impairments in the future.Learning and memory not only provide the foundations of cognition, but are also closely related to sensory and motor function. Neurodegenerative conditions such as Alzheimer＇s disease and Parkinson＇s disease are accompanied by deficits in synaptic func- tion and cognition to varying degrees. The discovery of long-term potentiation （LTP） of hippocampal synaptic transmission, which has been recognized as a classical model of learning and memory at the cellular level, has spurred substantial progress in the development of cognitive enhancers in the past 20 years. Following intensive investigations into LTP, a variety of compounds and biologically active substances have been found to modulate hippocampal LTP via numerous molecular mechanisms including regulating presynaptic neurotransmitter release, postsynaptic N-methyl D-aspartate （NMDA） receptor activity, postsynaptic signal transduction and gene transcription. This review focuses on the progress of investigations into the overarching mechanisms of LTP, the drugs modulating LTP and prospects for the development of new drugs for treating cognitive impairments in the future.

关 键 词：药物治疗 海马 生物活性物质 阿尔茨海默氏病 突触传递 电位 调制 分子机制 

分 类 号：Q426[生物学—神经生物学] TS252.1[生物学—生理学]