疏血通注射液对急性期脑出血的疗效观察  

Clinical observation of Shuxuetong injection for intracerebral hemorrhage at acute phase

作　　者：李华建[1] 王春芝[1] 于新华[1] 孙奎兴[1] 包敬玺[1] 李再松[1] 杨文辰[1] 

机构地区：[1]青岛大学医学院附属医院海阳分院(海阳市人民医院)神经外科,海阳265100

出　　处：《中华神经医学杂志》2010年第11期1158-1160,共3页Chinese Journal of Neuromedicine

摘　　要：目的 观察疏血通注射液对急性期脑出血患者的临床疗效.方法 选取60例符合条件的急性期脑出血患者并按随机数字表法分为治疗组（30例）和对照组（30例）.对照组采用常规治疗,治疗组在常规治疗基础上给予疏血通注射液6mL 1次/d静滴,连用15 d.入院第1天,治疗第7、15天行头颅CT检查测量血肿体积、血肿周围低密度容积的大小,应用美国国立卫生研究院卒中量表（NIHSS）进行神经功能缺损评分,同时监测两组患者血浆纤维蛋白原水平.结果 入院第1天,两组神经功能缺损评分、血肿体积、血肿周围低密度容积的大小、血浆纤维蛋白原水平比较差异无统计学意义（P＞0.05）.治疗第7、15天,治疗组神经功能缺损评分、血肿体积、血肿周围低密度容积的大小均明显低于对照组,比较差异有统计学意义（P＜0.05）.治疗第7、15天,两组血浆纤维蛋白原水平比较差异无统计学意义（P＞0.05）.结论 疏血通注射液能促进脑出血时的血肿吸收、血肿周围低密度区缩小和神经功能改善,不会引起血浆纤维蛋白原水平下降和血肿的扩大.Objective To observe the curative effect of Shuxuetong injection on intracerebral hemorrhage at acute phase. Methods Sixty patients with intracerebral hemorrhage at acute phase were randomly divided into treatment group and control group （n=30）. The treatment group intravenously received 6 mL Shuxuetong daily for 15 consecutive d and control group was treated with routine treatment. CT was performed to evaluate the volumes of hematomas, the changes of low-density areas surrounding the hematomas on the 1st, 7th and 15th d of treatment, respectively. The neurologic impairment evaluation scores were recorded with National Institutes of Health Stroke Scale （NIHSS）. Monitor on plasma fibrinogen level was performed in both groups. Results No significant differences on the volumes ofhematomas, low-density areas surrounding the hematomas, neurologic impairment evaluation scores, and plasma fibrinogen level were noted between the 2 groups on the admission day （P〉0.05）. On the 7th and 15th d of treatment, volumes of hematomas, low-density areas surrounding the hematomas and neurologic impairment evaluation scores in the treatment group reduced significantly as compared with those in the control group （P〈0.05）, however, plasma fibrinogen level was not statistically different between the 2 groups （P〉0.05）. Conclusion Shuxuetong injection is superior to routine treatment in reduction of volumes of hematomas, low-density areas surrounding the hematomas, neurologic impairment evaluation scores, but not in reduction of plasma fibrinogen level.

关 键 词：疏血通注射液 脑出血 脑水肿 凝血酶 

分 类 号：R686[医药卫生—骨科学]