针刺抗抑郁快速起效的内阿片肽机制  

A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression

作　　者：王欣君[1] 王玲玲[1] 

机构地区：[1]南京中医药大学针药结合实验室,江苏南京210029

出　　处：《中西医结合学报》2010年第11期1014-1017,共4页Journal of Chinese Integrative Medicine

基　　金：国家自然科学基金资助项目(No.30901923);教育部高等学校博士学科点专项科研基金资助项目(No.20093237110009)

摘　　要：临床和实验研究均表明针刺治疗抑郁症与5-羟色胺再摄取抑制剂抗抑郁药相比起效快速,以控制焦虑情绪和躯体胃肠不适感为特点。针刺治疗各种痛症取得稳定疗效的时间在1周左右,这与针刺抗抑郁快速起效的时间相同。针刺镇痛的主要通路是内阿片肽系统。阿片肽能够使患者产生愉悦感,减轻焦虑情绪和躯体胃肠不适感,目前的研究认为阿片肽具有抗抑郁作用。据此认为,针刺抗抑郁快速起效是通过针刺镇痛的主要通路———内阿片肽系统实现的。Clinical and experimental studies show that the onset of effect of acupuncture on depression is more rapid than selective serotonin reuptake inhibitors,a class of antidepressants.Acupuncture treatment is characterized by controlling anxiety and gastrointestinal discomfort.The onset time of acupuncture treatment for various pains is a week or so,which is the same as the rapid onset time of antidepressant effect of acupuncture,and the main pathway of acupuncture analgesia is through endogenous opioid system.Opioid peptides can produce pleasure,and decrease anxiety and gastrointestinal discomfort,so opioid peptides are considered to have antidepressant effect.Accordingly,the main pathway of acupuncture analgesia ？？ the endogenous opioid system,is considered a mechanism for rapid onset of acupuncture effects on depression.

关 键 词：针刺 抑郁症 内阿片肽 

分 类 号：R245[医药卫生—针灸推拿学]