Calponin-1和Transgelin蛋白在临产前后妊娠子宫平滑肌中的表达  

Expression of Calponin-1 and Transgelin in human uterine smooth muscles in non-labor and labor situation

作　　者：陈倩[1] 谷永红[1] 周昌菊[2] 胡灵玉[2] 彭长缨[1] 

机构地区：[1]中南大学湘雅三医院病理科,长沙410013 [2]中南大学湘雅三医院产科,长沙410013

出　　处：《中南大学学报（医学版）》2010年第10期1073-1079,共7页Journal of Central South University ：Medical Science

基　　金：湖南省科技厅科技计划项目(2008SK3115;2008SK3116)~~

摘　　要：目的:探讨调宁蛋白1(Calponin-1)和转凝蛋白(Transgelin)在临产前后子宫平滑肌组织中的表达及其在分娩发动中的作用机制。方法:选取14例初产妇的子宫体部及子宫下段平滑肌组织,分为未临产组及临产组。分别用免疫组织化学及Western印迹检测Calponin-1和Transgelin的表达水平。结果:临产组子宫体部和下段平滑肌组织Calponin-1的表达较未临产组明显升高(P<0.05)。临产组子宫体部平滑肌组织中Transgelin的表达较未临产组升高(P<0.05),而子宫下段平滑肌组织中Transgelin的表达2组差异无统计学意义(P>0.05)。结论:子宫体部和下段平滑肌组织中的Calponin-1和子宫体部平滑肌组织中的Transgelin可能参与了子宫平滑肌收缩的调节,与分娩发动关系密切。Objective To investigate the expression of Calponin-1 and Transgenlin in the uterine smooth muscles during normal labor on-sets,and to evaluate their effect on initiating the normal labor.Methods A total of 14 uterine bodies and lower segments of human pregnancy were divided to a non-labor group （NIL） and a labor group（IL）. Immunohistochemical technology and Western blot were used to determine the expression of Calponin-1 and Transgelin in the 2 groups. Results Immunohistochemical detection and Western blot showed that Calponin-1 protein in the uterine smooth muscle tissue of the body and the lower uterine segment of smooth muscle tissues had significant difference （P0.05）. The expression of Transgelin in the uterine body smooth muscle tissue in the IL was higher than that in the NIL（P0.05）. In the lower uterine segments of the smooth muscle,the expression of Transgelin was not significantly different in the 2 groups （P0.05）.Conclusion Calponin-1 of the uterine smooth muscle and Transgelin of the uterine body smooth muscle may involve in the regulation of uterine smooth muscle contractility,which is closely related to child birth launch.

关 键 词：调宁蛋白1 转凝蛋白 平滑肌 妊娠子宫 

分 类 号：R714[医药卫生—妇产科学]