脉冲磁场对脑损伤患者脑脊液中胰岛素样生长因子-1含量的影响及IGF-1对功能康复的作用  

Effects of pulsed magnetic field on insulin-like growth factor-1(IGF-1) in cerebrospinal fluid and effects of IGF-1 on functional recovery

作　　者：宋成宪[1] 范建中[1] 吴红瑛[1] 魏轶[1] 甄健荣[1] 

机构地区：[1]南方医科大学南方医院康复医学科,广东广州510515

出　　处：《南方医科大学学报》2010年第10期2288-2290,2294,共4页Journal of Southern Medical University

基　　金：广东省医学科研基金课题(A2007384)

摘　　要：目的研究脉冲磁疗对脑损伤患者脑脊液中胰岛素样生长因子-1(IGF-1)含量及IGF-1变化与患者日常生活活动能力(activities of daily living,ADL)恢复之间的相关性。方法将65例脑损伤恢复期患者随机分为试验组(35例)和对照组(30例)。试验组在常规治疗的基础上,加用头部脉冲磁场治疗(20～40mT,50Hz,20min/次,1次/d,共14d);对照组除未给予脉冲磁场治疗外,余治疗均与试验组基本相同。所有患者均经签署知情同意书后,在入组后第1天和第14天行腰椎穿刺检查,留取脑脊液2ml,并行Barthel指数(Barthel index BI)评定以了解患者的ADL能力,IGF-1含量的测定采用放射免疫法。结果经脉冲磁场治疗14d后,试验组脑脊液中IGF-1含量高于治疗前和对照组,差异有统计学意义(P<0.05);对照组脑脊液中IGF-1含量治疗前后无明显变化(P>0.05)。治疗后,试验组和对照组Barthel指数较前均明显改善(P<0.01),但试验组较对照组改善明显(P<0.05);且IGF-1的变化与BI变化之间具有正相关关系(r=0.283,P=0.022)。结论脉冲磁场可以使脑损伤患者脑脊液中IGF-1含量升高,并且IGF-1的升高可以促进患者的ADL能力的恢复,说明脉冲磁场在脑损伤患者的治疗中有一定的临床应用价值。Objective To study the effects of pulsed magnetic field on insulin-like growth factor-1（IGF-1） level in the cerebrospinal fluid（CSF） and the association of IGF-1 alterations with the activities of daily living（ADL） of patients with brain injury.Methods Sixty-five patients with brain injury were divided randomly into the control group（n=30） and magnetic therapy group（n=35）,both receiving conventional therapy and in the lattergroup,daily pulsed magnetic field treatment（20-40 mT,50 Hz,20 min per time,1 time per day） for 14 consecutive days were administered.On the first and 14th days of the treatment,2 ml CSF was collected from the cases patients forIGF-1 measurement by radioimmunoassay,and Barthel index（BI） was used to assess the ADL of the patients.Results After a 14-day treatment,IGF-1 level in the CSF were significantly increased in the magnetic group in comparison with the level before the treatment and with those in the control group（P0.05）.IGF-1 in the CSF underwent no significant changes in the control group（P0.05）.The scores of BI increased significantly in both groups afterthe treatment（P0.01）,but the increment was more obvious in the magnetic therapy group（P0.05）.A significant positive correlation was found between IGF-1 level in the CSF and BI in these patients（r=0.283,P=0.022）.Conclusion Pulsed magnetic field might increase IGF-1 level in the CSF of patients with brain injury to promote the recovery of the patients ADL,suggesting its potential clinical value in the treatment of brain injury.

关 键 词：脉冲磁场 胰岛素样生长因子-1(IGF-1) 脑损伤 日常生活活动能力 

分 类 号：R651.1[医药卫生—外科学]