中国汉族系统性红斑狼疮患者PTPN22基因多态性的初步研究  

Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients

作　　者：彭学标[1] 欧丽娜[1] 

机构地区：[1]南方医科大学南方医院皮肤风湿科,广东广州510515

出　　处：《南方医科大学学报》2010年第10期2390-2391,共2页Journal of Southern Medical University

基　　金：广东省医学科研课题(A2000379);中华医学会皮肤病学分会科研基金课题(2000)

摘　　要：目的探讨蛋白酪氨酸磷酸酶非受体型22(PTPN22)外显子14区域1858C/T单核苷酸多态性与系统性红斑狼疮(SLE)发病的相关性。方法采用PCR-RFLP方法分别对40例中国汉族SLE患者及20例健康对照者1858C/T位点进行多态性检测。结果 SLE患者和健康对照组PTPN22基因的1858位点CC、CT、TT基因型及C、T等位基因频率均无统计学差异。结论 PTPN22基因1858C/T单核苷酸多态性与中国汉族SLE发病无相关性。Objective To investigate the association between 1858C/T single nucleotide polymorphism on exon 14 of the protein tyrosine phosphatase nonreceptor-22（PTPN22） gene and systemic lupus erythematosus in Chinese Han patients.Methods Forty Chinese Han patients with SLE and 20 normal control subjects were enrolled in the study,and PTPN22 gene 1858 C/T polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）.Results No significant difference was found in the CC,CT,and TT genotype frequencies orin the C and T allele frequencies between the SLE patients and the normal controls.Conclusion 1858C/T on PTPN22 gene might not be associated with the susceptibility of SLE in Chinese Han population.

关 键 词：蛋白酪氨酸磷酸酶非受体型22 多态性 系统性 红斑狼疮 

分 类 号：R593.241[医药卫生—内科学]