生物遥测法监测清醒状态下Beagle犬的心电生理特性  

Monitoring on Cardiovascular and Physiology Characteristics of Beagle Dog by Telemetry

作　　者：李娜[1] 王文誉[1] 奚剑飞[1] 徐皓[1] 丁爽爽[1] 张周[1] 

机构地区：[1]中国科学院上海药物研究所,上海201203

出　　处：《实验动物与比较医学》2010年第5期354-358,共5页Laboratory Animal and Comparative Medicine

基　　金：上海市科学技术委员会科研计划项目（08140900400）,重人新药刨制国家科技重大专项（2009ZX09301-001）,中国科学院战略生物资源技术支撑体系专项（项目编号：CZBZX-1）

摘　　要：目的 在Beagle犬侧腹部肌肉组织上埋置传感器,采用生物遥测法监测清醒状态下动物的心率、体温、血流动力学及心电图各项指标. 方法 手术埋置传感器,恢复两周后,采用Dataquest A.R.T.2.3系统连续监测24 h内的心率、体温、血流动力学和心电图指标,并于次周重复一次. 结果 在整个实验过程中,该方法所监测指标基本维持正常水平,但上午10：00部分指标升至最高,心率值达到95.58±15.89次/分钟,收缩压、平均动脉压及舒张压也分别升至最高达152.37±10.67 mmHg,109.37±5.90 mmHg和87.73±5.01 mmHg,且两次实验结果间比较也没有明显差异（P＞0.05）. 结论 体内埋置传感器方法可以更加准确的监测清醒状态下Beagle犬的各项心血管指标,且动物在饮食过程中呈现出较高兴奋的状态.Objective To monitor the heart rate, temperature, hemodynamics and electrocardio- gram of beagle dog by telemetry. Methods After two weeks of imbedding the sensor in abdomen muscle, the heart rate, temperature, hemodynamics and electrocardiogram were monitored continuously for 24 hours by Dataquest A.R.T. 2.3, and repeated on next week. Results In all of the monitor process, every index maintain the normal level, but the heart rate rise to the highest about 95.58±15.89 beat per minute at 10 ： 00 am, with the systolic pressure, mean arterial blood pressure and diastolic pressure were 152.37±10.67 mmHg, 109.37±5.90 mmHg and 87.73±5.01 mmHg respectively. No differences were found between the two detection（P〉0.05）. Conclusions The cardiovascular cardiovascular and physiology Characteristics of Beagle dog could been monitored more exactly by telemetry, and the beagle dog was very excited on diet.

关 键 词：传感器 生物遥测 心率 体温 血流动力学 心电图 

分 类 号：Q95-33[生物学—动物学]