碱性成纤维细胞生长因子在自体脂肪颗粒填充面部凹陷中的作用  

Effects of basic fibroblast growth factor on treating facial depression deformity with autologous fat transplantation

作　　者：李卫华[1] 孙志成[1] 王文[1] 

机构地区：[1]武警医学院附属医院烧伤整形科,天津市300162

出　　处：《中国组织工程研究与临床康复》2010年第41期7753-7756,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：武警医学院青年基金(WYQ2006-14);课题名称:碱性成纤维细胞生长因子对人前脂肪细胞增殖和分化的影响~~

摘　　要：背景:碱性成纤维细胞生长因子具有明显的促进细胞增殖、加速移植物血管化的作用,而且可以促进人前脂肪细胞向成熟脂肪细胞分化。目的:观察成纤维细胞生长因子在自体脂肪颗粒移植治疗面部凹陷中的作用,评价其治疗效果。方法:纳入武警医学院附属医院应用自体脂肪颗粒注射移植治疗面部凹陷的患者52例,患者按治疗的先后时间顺序分为对照组和碱性成纤维细胞生长因子组。对照组患者只注射自体脂肪颗粒进行治疗,碱性成纤维细胞生长因子组在注射自体脂肪颗粒的基础上加入碱性成纤维细胞生长因子。两组患者术后6个月随访,通过照相对比凹陷填充效果。结果与结论:52例患者面部凹陷均得到不同程度的改善。对照组19例患者充填效果,优4例,良6例,优良率53%,有12例患者进行了2次注射,比例为63%。成纤维细胞生长因子组33例患者充填效果,优14例,良12例,优良率79%,有11例患者进行了2次脂肪注射,比例为33%。两组优良率和二次注射率比较,有显著性差异(P<0.05)。可见碱性成纤维细胞生长因子局部应用可以明显提高面部凹陷的填充效果,安全有效。BACKGROUND： Basic fibroblast growth factor （bFGF） plays a promotive effect on cell proliferation and graft vascularization, which can facilitate human preadipocytes differentiate into adipocytes. OBJECTIVE： To evaluate the effect of basic fibroblast growth factor on repairing facial depression deformity with autologous fat particle transplantation. METHODS： A total of 54 patients with facial depression treated with autologous fat particle transplantation at the Affiliated Hospital of Medical College of Chinese People＇s Armed Police Force were selected. The patients were divided into control and bFGF groups according to chronological order. Patients in the control group were treated with pure fat particle transplantation, and patients in the bFGF group were treated by fat particle transplantation combined with bFGF. The therapeutic effects were observed through the comparison of the pre-post facial photos. RESULTS AND CONCLUSION： The depression deformity of all the 54 patients was improved. There were 4 excellent and 6 good in the control group, with excellent and good rate of 63%. There were 12 patients received a second fat injection, and the ratio was 63.2%. In bFGF group, 14 excellent and 12 good, the excellent and good rate was 79%. Only 11 patients received a second fat injection, with the ratio of 33.3%. There was a significant statistical difference between the two groups （P0.05）. Accordingly, local application of bFGF can enhance filling efficiency of facial depression.

关 键 词：自体脂肪 脂肪移植 碱性成纤维细胞生长因子 面部凹陷 治疗效果 

分 类 号：R318[医药卫生—生物医学工程]