妊高征患者胎盘中一氧化氮合酶活性的变化及其意义  

The Changes of Placental Nitric Oxide Synthase Activities in Patients with Pregnancy induced Hypertension.

作　　者：周容[1] 李维敏[1] 曹泽毅[1] 刘淑云[1] 熊庆[1] 肖邦良[2] 程薇波[2] 

机构地区：[1]华西医科大学附二院妇产科,成都610041 [2]华西医科大学公共卫生学院

出　　处：《中华围产医学杂志》1999年第2期79-81,共3页Chinese Journal of Perinatal Medicine

摘　　要：目的　探讨胎盘中一氧化氮合酶（ＮＯＳ） 活性在妊高征发病中的作用。　方法　采用酶组织化学法（ 四唑盐法） 研究了３２ 例妊高征患者胎盘和３２ 例正常足月孕胎盘中一氧化氮合酶（ＮＯＳ）活性的变化情况。　结果　１．在正常足月孕胎盘和妊高征患者胎盘的绒毛血管内皮细胞和绒毛合体滋养细胞的胞浆内均存在ＮＯＳ 活性。２ ．妊高征患者胎盘中ＮＯＳ 活性显著低于正常足月孕者（ Ｐ＜ ０．０５） ，且轻度妊高征患者胎盘中ＮＯＳ活性显著高于中度及重度患者（Ｐ＜ ０．０２５，Ｐ＜ ０．０２５） 。３．妊高征患者血压与ＮＯＳ活性之间存在显著的负相关（ Ｐ＜ ０．０１）。Objective To determine whether the activities of placental nitric oxide synthase (NOS) were changed in pregnancy induced hypertension (PIH). Methods The NOS of the placentae of 32 patients with PIH and 32 normal pregnant women were investigated by enzymehistochemistry ( Tetrazoleun method). Results 1 There were NOS activities in placental tissues from PIH and normal term pregnant women. They were all localized in the endothelium of the vessel in placental villi and syncytiotrophoblast cells. 2. The activities of placental NOS decreased significantly in patients with PIH when compared with those of normal pregnant women. The activities of placental NOS in mild patients were higher than those of moderate or severe patients respectively ( P <0.025, P <0.025). 3. There was a negative correlation between the blood pressure and the activities of placental NOS ( P <0.01). Conclusion The decrease of the activities of placental NOS may play a crucial role in the pathogenesis of PIH.

关 键 词：一氧化氮合酶 酶组织化学 妊娠高血压 胎盘 

分 类 号：R714.246[医药卫生—妇产科学]