急性心肌梗死患者治疗前后血浆ET-1、血清6-酮-PGF_(1α)、TXB_2和GMP-140水平检测的临床意义  

Clinical significance of changes of plasma ET-1,6-keto-PGF_(1α),TXB_2 and GMP-140 levels after treatment in patients with AMI

作　　者：王维 牛新海 陶纯钢 张翠英 

机构地区：[1]江苏省镇江市丹徒区人民医院,212028

出　　处：《中国医学创新》2010年第33期1-2,共2页Medical Innovation of China

摘　　要：目的探讨急性心肌梗死患者治疗前后血浆ET-1、血清6-酮-PGF_(1α)、TXB_2和GMP-140水平的变化及临床意义。方法应用放射免疫分析法对33例急性心肌梗死患者治疗前后进行了血浆ET-1、血清6-酮-PGF_(1α)、TXB_2和GMP-140水平测定,并与35名正常人作比较。结果急性心肌梗死患者在治疗前后血浆ET-1、TXB_2和GMP-140水平非常显著地高于正常人组(P<0,01),而血清6-酮-PGF_(1α)水平又明显低于正常人组(P<0.05),经治疗1个月后与正常人比较仍有差异(P<0.05)。血浆ET-1水平和TXB_2、GMP-140水平呈正相关(r=0.4986,0.5014,P<0.05),6-酮-PGF_(1α)水平呈负相关(r=-0.4712,P<0.05)。结论测定急性心肌梗死患者治疗前后血浆ET-1、血清6-酮-PGF_(1α)、TXB_2和GMP-140水平变化对观察病情和预后判定具有重要的临床价值。Objective To explore the significance of changes of plasma ET - 1 and Serum 6 - keto - PGF1α, TXB2 and GMP - 140 levels after treatment in patients with AMI. Methods Plasma ET - 1 and Serum 6 -keto - PGF1α ,TXB2 and GMP - 140 levels in 33 patients with AMI both before and after treatment as well as in 35 controls were detected with RIA. Results Before treatment, plasma ET - 1 and Serum TXB2 and GMP - 140 levels were significantly higher than those in controls （P 〈 0.01 ）, while the set-am 6 - keto -PGF1α levels were lower than those in controls （P 〈 0. 05 ）, after treatment for 1 month, the levels were not significantly different from those in controls （P 〈 0.05 ）, serum TXB2 , GMP - 140 levels were correlated （ r = 0. 4986,0. 5014,P 〈 0. 05 ）, while serum 6 - keto - PGF1α negatively correlated （ r = - 0. 4712, P 〈 0.05 ）. Conclusion Detection of ET - 1, 6 - keto - PGF1α , TXB2 and GMP - 140 contents after treatment might be of clinical importance in observation and prognostic judgment upon the status of patients with acute myocardial infarction.

关 键 词：急性心肌梗死 内皮素-1 6-酮-前列环素F1Α 血栓素-B2 血小板颗粒膜蛋白-140 

分 类 号：R542.22[医药卫生—心血管疾病]