^(188)Re—HEDP的制备研究  

A study on preparation of ^(188)Re-HEDP

作　　者：尹端沚[1,2] 郭子丽[1] 张炯[1,2] 闵小锋 于俊峰[1] 李卜森 胡伟青[1,2] 何蔚瑜[1,2] 汪勇先[1,2] 

机构地区：[1]中国科学院上海原子核研究所,上海201800 [2]上海科兴药业公司,上海201800

出　　处：《核技术》1999年第6期374-377,共4页Nuclear Techniques

基　　金：国际原子能机构基金

摘　　要：为了研制一种新型的骨转移疼痛缓解治疗剂－(188)Re－HEDP，合成了配体HEDP，产率大于90％，并用自制(188)W－(188)Re发生器产生的(188)Re标记HEDP。系统地研究了HEDP、SnCl2和VitC的量，溶液pH值，反应温度和反应时间对标记产额的影响。标记物经HPLC和PC检测，放化纯度及标记率大于95％。在体外12h稳定。The development of a new potential bone pain palliation agent, 188Re--HEDP,was described here. The ligand HEDP was synthesized giving a yield over 90% and the is8Re--HEDP was prepared with generator--produced 188Re. Labelling yield and radiochemical purity were determined by TLC and HPLC. The optimal labelling conditions were systematically investigated and the kit formulation was developed.The labelling efficiency of 188Re--HEDP was greater than 95%, and the radiochemicalpurity was still over 90% after stored at 15℃ for 12 hrs.

关 键 词：HEDP 化学合成 镭188 骨转移 疼痛治疗剂 

分 类 号：R817.9[医药卫生—影像医学与核医学] TQ462.2[医药卫生—放射医学]