血管紧张素转化酶活性变化在2型糖尿病早期肾损害诊断中的价值  

Value of angiotensin-converting-enzyme activity changes in the diagnosis of early renal damage in type 2 diabetes patients

作　　者：王毅[1] 张一兵[2] 罗喜钢[2] 金辉[2] 

机构地区：[1]辽宁医学院,辽宁锦州121001 [2]辽宁医学院附属第三医院

出　　处：《山东医药》2010年第43期31-33,共3页Shandong Medical Journal

摘　　要：目的探讨血管紧张素转化酶(ACE)在2型糖尿病早期肾损害中的诊断价值。方法采用全自动生化仪速率法检测65例2型糖尿病患者(观察组)及50例查体健康者(对照组)血、尿ACE活性,并对尿ACE与尿N-乙酰-β-D氨基葡萄糖苷酶(UNAG)、尿微量白蛋白(mAlb)及血ACE行Pearson相关分析。结果观察组尿ACE、mAlb、UNAG均明显高于对照组(P均<0.05),尿ACE活性随糖尿病病情加重而逐渐增高。相关性分析示尿ACE与UNAG、mAlb均呈正相关(r值分别为0.757、0.796,P均<0.001),与血ACE无明显相关性。结论尿ACE活性变化对2型糖尿病早期肾脏损害诊断有较好的临床价值,可作为筛选指标。Objective To discuss the value of angiotensin-converting-enzyme（ACE） in the diagnosis of early renal damage in type 2 diabetes patients.Methods The blood,urinary ACE activity were detected using an automatic biochemical analyzer by rate method,in 65 patients with type 2 diabetic patients（observation group） and 50 healthy controls（control group）,the urinary ACE and urinary N-acetyl-1-β-D glucosaminidase（UNAG） level,urine microalbumin（mAlb） and serum ACE were identified Pearson correlation analysis.Results The urinary ACE,mAlb,UNAG in the observation group were significantly higher than those in the control group（P0.05）,the urinary ACE activity increased progressively with the development of diabetic.Correlation analysis showed that urinary ACE was correlated with UNAG and mAlb（r values were 0.757,0.796,both P0.001）,but not with serum ACE.Conclusions The changes of urinary ACE activity has good clinical value in the diagnosis of early renal damage in type 2 diabetes patients.

关 键 词：血管紧张素转化酶 微量白蛋白 N-乙酰-Β-D氨基葡萄糖苷酶 糖尿病 非胰岛素依赖型 

分 类 号：R587.1[医药卫生—内分泌]