海南黎族人群对氧磷酶3基因Ala99Ala多态性的分布  

Polymorphism distribution of paraoxonase 3 gene Ala99Ala in Hainan Li nationality

作　　者：邬强[1] 李林江[2] 李冬梅[2] 傅琼瑶[1] 吴洁[1] 范志刚[1] 裴华[1] 钱士匀[1] 

机构地区：[1]海南医学院热带医学与检验医学院,海南海口571101 [2]海南医学院

出　　处：《海南医学院学报》2010年第11期1389-1391,共3页Journal of Hainan Medical University

基　　金：海南省自然科学基金项目(2008-30837)~~

摘　　要：目的:分析海南黎族人群对氧磷酶3(paraoxonase 3,PON3)基因Ala99Ala位点多态性的分布情况,为研究PON3相关性疾病的发病机制奠定基础。方法:采用PCR-RFLP技术对海南150名黎族健康个体进行PON3基因Ala99Ala位点多态性分析,获得其基因频率分布规律,并与国外其他人群PON3等位基因的多态性进行比较。结果:海南黎族健康人群PON3基因Ala99Ala位点存在多态性,基因频率分别为AA 0.58、GG 0.08、AG 0.34;在此位点海南黎族人群基因型频率与国外其他种族人群比较,分布存在着明显差异(P均<0.01)。结论:我国海南黎族人群PON3基因Ala99Ala多态性分布不同于国外其他种族,不同国家种族间分布差异机制需要更多研究来阐明。Objective; To analyze the genetic polymorphism of paraoxonase 3（PON3） Ala99Ala in Hainan Li nationality in order to provide evidence for the research of PON3 related diseases. Methods： PON3 gene polymorphism of 150 healthy individuals that were Li nationality in Hainan province was studied by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）, the genotype frequencies were obtained and compared with that were collected from foreign population. Results： PON3 gene Ala99Ala polymorphism was demonstrated, genotype frequency was AA 0.58, GG 0.08, AG 0.34 respectively. The frequencies of the PON3 Ala99Ala genotype collected from Hainan Li nationality were significantly different from that of foreign population （P〈0.05）. Conclusion： There is a significant difference in PON3 genotype between Li nationality and other race of people, while the mechanism still needs further study.

关 键 词：对氧磷酶3 遗传多态性 黎族 分布 

分 类 号：R596.1[医药卫生—内科学]