2D NMR研究呋喃糖Grignard加成产物的绝对构型(英文)  

STUDY ON THE SYNTHESIS AND ABSOLUTE CONFIGURATIONS OF GRIGNARD ADDITION PRODUCTS OF FURANOSES BY 2D NMR *

作　　者：张铭龙[1] 崔育新[1] 刘雪辉[1] 李敬光[1] 马灵台 张礼和[1] 

机构地区：[1]北京医科大学药学院天然药物及仿生药物国家重点实验室

出　　处：《波谱学杂志》1999年第3期218-224,共7页Chinese Journal of Magnetic Resonance

摘　　要：通过对相应呋喃糖进行Ｇｒｉｇｎａｒｄ亲和加成合成了苯基及苄基取代呋喃糖．所得主要产物的结构和绝对构型通过二维核磁共振进行了研究．其结果通过计算机分子模拟优化，并进行了比较和确认．Phenyl and benzyl furanoses have been prepared stereoselectively by Grignard nucleophilic addition to their correspondent furanoses. Their structures and absolute configurations were studied and described by measuring the two dimensional NMR spectroscopy. The results have been compared and confirmed by computational optimizing model data.

关 键 词：呋喃糖 亲和加成 绝对构型 二维 核磁共振 

分 类 号：O629.1[理学—有机化学] O626.11[理学—化学]